Evaluation of racial disparities in pediatric optic pathway glioma incidence: Results from the Surveillance, Epidemiology, and End Results Program, 2000-2014.
Evaluation of racial disparities in pediatric optic pathway glioma incidence: Results from the Surveillance, Epidemiology, and End Results Program, 2000-2014.
复制标题
DOI：
10.1016/j.canep.2018.04.005
复制
发表时间：
2018-06
影响因子：
2.6
通讯作者：
Schiffman JD
中科院分区：
文献类型：
--
作者：
Peckham-Gregory EC;Montenegro RE;Stevenson DA;Viskochil DH;Scheurer ME;Lupo PJ;Schiffman JD
儿童癌症存在种族倾向；然而，不同种族/民族的视路胶质瘤(OPG)风险差异尚不明确。我们在美国多个州的癌症监测登记中估计了不同种族/民族的OPG发病率的差异。OPG数据来自2000-2014年的监测、流行病学和最终结果(SEER-18)计划。种族/族裔分类为：白人、黑人、亚洲人、其他人和拉丁裔/a(“西班牙裔-西班牙裔-拉丁裔”)。拉丁裔/a包括所有种族，而所有其他类别不包括被确定为拉丁裔/a的那些。年龄调整后的发病率和比率(IRR)在SEER-STAT(v8.3.4)中生成，可信区间(CI)为95%。709例0-19岁OPG病例的数据摘自SEER-18。少数民族儿童的年龄调整后OPG发病率低于白人儿童(IRRBlack=0.38，95%CI：0.28-0.50；IRRAsian=0.41，95%CI：0.29-0.58；IRRLatino/a=0.39，95%CI：0.32-0.48)。在高危年龄组(0-4岁、5-9岁)的亚组分析中，少数民族儿童的发病率低于白人儿童。拉丁裔/AS的具体模式也出现了。与白人相比，0至4岁的拉丁裔/a儿童的发病率在所有种族/族裔群体中最低(分别为每10万人年0.24人和每10万人年0.66人)，而在5至9岁的儿童中，黑人和亚洲儿童的发病率最低(每10万人年0.08人)。在白人儿童中，OPGs的发生率最高。这项研究是评估不同种族/民族OPG易感性差异的最大研究之一。这些发现可能会为未来的研究提供信息，这些研究试图评估这种儿科肿瘤的修饰因素，包括肿瘤的发生、治疗、结果和长期的晚期影响。
Racial predilection to pediatric cancer exists; however optic pathway glioma (OPG) risk differences by race/ethnicity are undefined. We estimated differences in OPG incidence across racial/ethnic groups in a multi-state cancer surveillance registry in the United States. OPG data were obtained from the Surveillance, Epidemiology, and End Results (SEER-18) program, 2000–2014. Race/ethnicity was categorized as: White; Black; Asian; Other; and Latino/a (“Spanish-Hispanic-Latino”). Latino/a included all races, while all other categories excluded those identified as Latino/a. Age-adjusted incidence rates and rate ratios (IRR) with 95% confidence intervals (CIs) were generated in SEER-STAT (v8.3.4). Data on 709 OPG cases ages 0–19 were abstracted from SEER-18. Minority children experienced lower age-adjusted OPG incidence rates compared to White children (IRRBlack=0.38, 95% CI: 0.28–0.50; IRRAsian=0.41, 95% CI: 0.29–0.58; and IRRLatino/a=0.39, 95% CI: 0.32–0.48). In subgroup analyses among the highest risk age categories (0–4, 5–9), minority children experienced lower incidence rates compared to White children. Specific patterns for Latinos/as also emerged. Latino/a children ages 0–4 experienced the lowest incidence rates of all racial/ethnic groups compared to Whites (0.24 per 100,000 person-years versus 0.66 per 100,000 person-years, respectively), whereas among those ages 5–9, Black and Asian children experienced the lowest incidence rates (0.08 per 100,000 person-years each). Incidence of OPGs was highest among White children. This study represents one of the largest to assess differences in OPG susceptibility by race/ethnicity. These findings may inform future studies that seek to evaluate modifying factors for this pediatric tumor including tumorigenesis, treatment, outcome, and long-term late effects.
登录
查看更多内容
影响因子：
2.6
作者：
Park, Henry S;Lloyd, Shane;Yu, James B
通讯作者：
Yu, James B
影响因子：
2
作者：
King, A;Listernick, R;Gutmann, DH
通讯作者：
Gutmann, DH
影响因子：
3.2
作者：
Kalin-Hajdu, Evan;Decarie, Jean-Claude;Ospina, Luis H.
通讯作者：
Ospina, Luis H.
影响因子：
0.7
作者：
Ertiaei, Abolhasan;Hanaei, Sara;Nejat, Farideh
通讯作者：
Nejat, Farideh
影响因子：
0.7
作者：
Silva, MM;Goldman, S;Tomita, T
通讯作者：
Tomita, T