Cardiac 64-Multislice Computed Tomography Reveals Increased Epicardial Fat Volume in Patients With Acute Coronary Syndrome
Cardiac 64-Multislice Computed Tomography Reveals Increased Epicardial Fat Volume in Patients With Acute Coronary Syndrome
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DOI：
10.1016/j.amjcard.2011.06.012
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发表时间：
2011-10-15
影响因子：
2.8
通讯作者：
Murohara, Toyoaki
中科院分区：
文献类型：
--
作者：
Harada, Ken;Amano, Tetsuya;Murohara, Toyoaki
冠状动脉周围心外膜脂肪释放的炎性细胞因子可调节冠状动脉并促进冠状动脉粥样硬化。我们评估了急性冠脉综合征（ACS）患者心外膜脂肪体积（EFV）增加的假设。使用64层计算机断层扫描测量了80例因ACS住院的日本患者的EFV。ACS组包括51例ST段抬高型心肌梗死患者和29例非ST段抬高型心肌梗死患者。所有患者在住院期间均接受了急诊冠状动脉成形术和64层螺旋CT扫描。对照组包括连续90例疑似ACS的门诊患者，其冠状动脉计算机断层扫描结果正常。ACS患者的EFV大于对照组（117 47 vs 95 +/- 33 ml，p <100 ml与ACS独立相关（比值比2.84，95%置信区间1.17 - 6.87，p = 0.021）。受试者操作者特征分析确定临界值为100.3 ml，ACS的敏感性为75%，特异性为60%（曲线下面积0.692，95%置信区间0.596 - 0.777，p
Inflammatory cytokines released from epicardial fat around coronary arteries may modulate the coronary arteries and promote coronary atherosclerosis. We assessed the hypothesis that epicardial fat volume (EFV) is increased in patients with acute coronary syndrome (ACS). EFV was measured in 80 Japanese patients hospitalized for ACS using 64-multislice computed tomography. The ACS group included 51 patients with ST-segment elevated myocardial infarction and 29 patients with non-ST-segment elevated myocardial infarction. All patients underwent emergency coronary angioplasty and 64-multislice computed tomographic scanning during hospitalization. The control group included 90 consecutive outpatients with suspected ACS whose coronary computed tomographic results were normal. EFV was larger in patients with ACS than in the control group (117 47 vs 95 +/- 33 ml, p 100 ml was independently associated with ACS (odds ratio 2.84, 95% confidence interval 1.17 to 6.87, p = 0.021). Receiver operator characteristic analysis determined a cut-off value of 100.3 ml with a sensitivity of 75% and a specificity of 60% for ACS (area under the curve 0.692, 95% confidence interval 0.596 to 0.777, p