Canine T-cell lymphomas: A morphological, immunological, and clinical study of 46 new cases
Canine T-cell lymphomas: A morphological, immunological, and clinical study of 46 new cases
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DOI：
10.1354/vp.39-1-92
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发表时间：
2002-01-01
影响因子：
2.4
通讯作者：
Magnol, JP
中科院分区：
文献类型：
--
作者：
Fournel-Fleury, C;Ponce, F;Magnol, JP
本研究的目的是报道在140例经免疫表型鉴定的淋巴瘤中新发现的46例犬T细胞淋巴瘤(发病率32.8%)。根据与犬种相适应的最新基尔分类，13例为低级别淋巴瘤，33例为高度恶性淋巴瘤，在低级别淋巴瘤中，5例为小透明细胞淋巴瘤。其中3例为多形性小细胞淋巴瘤，5例为真菌样肉芽肿。在高级别病例中，有L一型多形性混合型。小-。大细胞淋巴瘤，多形性大细胞淋巴瘤6例，淋巴母细胞淋巴瘤11例，无法分类的高级别浆细胞样淋巴瘤5例。根据细胞形态(核不规则、胞浆清晰)(30/46例)、T细胞带型和毛细血管后小静脉的存在(22/46例)，细胞组织学特征高度提示T细胞表型。46例患者均为CD3(+)CD79a，34例患者中，13例为CD4(+)CD8，13例为CD8，8例为CD4CD8双阳性或双阴性。多形性混合性淋巴瘤以CD4+CD8为主(6/7)，淋巴母细胞性淋巴瘤以双阳性或双阴性为主(6/8)。主要临床、血液学和生化特征为全身性(28/46)或区域性淋巴结病(16/46)、肝脾肿大(15/46)、结外侵犯(11/46)、纵隔肿块(9/46)和白血病(8/46)，主要见于淋巴母细胞淋巴瘤和高钙血症(16/46)。
The aim of this study is to report 46 new cases of canine T-cell lymphomas among a series of 140 lymphomas studied by immunophenotyping (incidence 32.8%). According to the updated Kiel classification adapted to the canine species, 13 were classified as low-grade and 33 as high-grade lymphomas, Among the low-grade lymphomas, five were small clear-cell lymphomas. three were pleomorphic small-cell lymphomas, and five mycosis fungoides. Among the high-grade cases, there were l I pleomorphic mixed-. small-. and large-cell lymphomas, 6 pleomorphic large-cell lymphomas, 11 lymphoblastic lymphomas, and 5 unclassifiable high-grade plasmacytoid lymphomas. The cytohistologic features were highly suggestive of a T-cell phenotype on the basis of cell morphology (irregular nuclei and clear cytoplasms) (30/46 cases), a T-cell zone pattern, and the presence of hyperplastic postcapillary venules (22/46 cases). All 46 cases were CD3(+) CD79a, and among 34 cases investigated for CD4 and CD8 expression, 13 were CD4(+) CD8, 13 were CD8 CD4, and 8 were CD4CD8 double positive or double negative. The pleomorphic mixed lymphomas were mainly CD4(+)CD8 (6/7) and the lymphoblastic lymphomas were double positive or double negative (6/8). The main clinical, hematologic, and biochemical features were generalized (28/46) or regional lymphadenopathy ( 16/46), hepatosplenomegaly (15/46), extranodal involvement (11/46), mediastinal mass (9/46), and leukemia (8/46), which were mainly present in cases of lymphoblastic lymphomas and hypercalcemia (16/46).