Fitness consequences of a non-recombining sex-ratio drive chromosome can explain its prevalence in the wild
Fitness consequences of a non-recombining sex-ratio drive chromosome can explain its prevalence in the wild
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DOI：
10.1098/rspb.2019.2529
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发表时间：
2019-12-18
影响因子：
4.7
通讯作者：
Hall, David W.
中科院分区：
文献类型：
--
作者：
Dyer, Kelly A.;Hall, David W.
了解基因驱动系统对宿主适应性的多效性后果对于预测其在宿主种群中的传播至关重要。在这里，我们研究性比（SR）的X染色体驱动的果蝇recens，SR导致死亡的Y精子在男性运营商。SR雄性只生下女儿，女儿都携带SR，因此染色体具有传播优势。SR染色体的流行似乎稳定，这表明多效性成本。以前的研究表明，SR纯合子的女性是不育的，在这里，我们测试额外的健身成本的SR。我们发现，SR杂合子的女性生育能力降低，男性SR携带者在精子竞争的条件下生育能力降低。然后，我们使用我们的健身估计参数化SR驱动器的理论模型，并表明生殖力和精子竞争性能的下降可以解释所观察到的自然种群中SR的患病率。此外，我们发现，预期的SR染色体的平衡频率是特别敏感的程度，多次交配和精子竞争的表现。总之，我们的数据表明，在基因驱动系统的开发过程中，应该仔细考虑生物体的交配系统。
Understanding the pleiotropic consequences of gene drive systems on host fitness is essential to predict their spread through a host population. Here, we study sex-ratio (SR) X-chromosome drive in the fly Drosophila recens, where SR causes the death of Y-bearing sperm in male carriers. SR males only sire daughters, which all carry SR, thus giving the chromosome a transmission advantage. The prevalence of the SR chromosome appears stable, suggesting pleiotropic costs. It was previously shown that females homozygous for SR are sterile, and here, we test for additional fitness costs of SR. We found that females heterozygous for SR have reduced fecundity and that male SR carriers have reduced fertility in conditions of sperm competition. We then use our fitness estimates to parametrize theoretical models of SR drive and show that the decrease in fecundity and sperm competition performance can account for the observed prevalence of SR in natural populations. In addition, we found that the expected equilibrium frequency of the SR chromosome is particularly sensitive to the degree of multiple mating and performance in sperm competition. Together, our data suggest that the mating system of the organism should be carefully considered during the development of gene drive systems.