Characterization of proteinuria using random urine samples.
Characterization of proteinuria using random urine samples.
复制标题
使用随机尿液样本表征蛋白尿。
DOI：
--
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Hou Mt
中科院分区：
文献类型：
--
作者：
Hou Mt
比较正常人和肾脏疾病患者尿白蛋白/肌酐比值（Ualb/Ucr）与定量白蛋白排泄的关系。尿白蛋白排泄量为3.4 - 4，699 mg/m2/d，Ualb/cr为5.3 - 6，600 μ g/mg;相关性非常显著（r = 0.979，p <0.001，n = 20）。为了使用随机尿液样本表征正常蛋白尿，从279名健康受试者（2个月至62岁）获得样本。测定所有样品中的总蛋白、白蛋白和溶菌酶。采用随机尿白蛋白/尿肌酐比值（Ualb/Ucr）、尿白蛋白/尿蛋白比值（Ualb/Up）和尿溶菌酶/尿白蛋白比值（Uly/Ualb）评价肾小球通透性和肾小管功能。Ualb/Ucr在小于4岁的儿童中较高，尽管Ualb/Up或Uly/Ualb没有发现与年龄相关的差异。此外，未观察到雄性和雌性之间的差异，并提供了正常参考值。本研究结果支持使用Ualb/Ucr作为尿白蛋白排泄的估计值，并使用肾小球和肾小管功能标志物表征正常蛋白尿。
: The urinary albumin to creatinine ratio (Ualb/Ucr) was compared with quantitative albumin excretion in normal subjects and patients with renal disease. Urinary albumin excretion varied from 3.4 to 4,699 mg/m2/day and Ualb/cr from 5.3 to 6,600 micrograms/mg; the correlation was highly significant (r = .979, p less than .001, n = 20). To characterize normal proteinuria using random urine samples, specimens were obtained from 279 healthy subjects (2 months - 62 years). Total protein, albumin and lysozyme were measured in all samples. Glomerular permeability and tubular function were assessed using the random Ualb/Ucr, the urinary albumin to protein ratio (Ualb/Up) and the urinary lysozyme to albumin ratio (Uly/Ualb). Ualb/Ucr was higher in children less than four years although no age-related differences were noted for Ualb/Up or Uly/Ualb. Furthermore, no differences were seen between males and females and normal reference values are provided. The results of this study support the use of Ualb/Ucr as an estimate of urinary albumin excretion and characterizes normal proteinuria using markers of both glomerular and tubular function.