Prognostic value of 18F-fluorodeoxyglucose PET/computed tomography metabolic parameters measured in the primary tumor and suspicious lymph nodes before neoadjuvant therapy in patients with esophageal carcinoma
Prognostic value of 18F-fluorodeoxyglucose PET/computed tomography metabolic parameters measured in the primary tumor and suspicious lymph nodes before neoadjuvant therapy in patients with esophageal carcinoma
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DOI：
10.1097/mnm.0000000000001347
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发表时间：
2021-04-01
影响因子：
1.5
通讯作者：
Cecconello, Ivan
中科院分区：
文献类型：
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作者：
Tustumi, Francisco;Duarte, Paulo Schiavom;Cecconello, Ivan
背景18-氟脱氧葡萄糖PET/CT（F-18-FDGPET/CT）代谢参数是多种肿瘤的预后指标。本研究旨在评估最大和平均标准化摄取值的预后价值（SUVmax和SUVavg），代谢肿瘤值（MTV），和总病变糖酵解（TLG）测量的原发肿瘤和可疑的淋巴结preneoadjuvant治疗的患者提交手术切除食管癌。评估CT新辅助治疗前的情况。评估原发肿瘤和可疑淋巴结中SUV、MTV和TLG与总生存率的相关性。还分析了其他潜在的混杂变量，如年龄、性别、临床分期和组织学亚型。采用Kaplan-Meier曲线、log-rank检验和考克斯回归分析。结果单因素分析显示，原发肿瘤的MTV和TLG、可疑淋巴结的SUV、年龄、组织学类型和临床分期与术后生存有关（P
BackgroundF-18-fluorodeoxyglucose PET/computed tomography (F-18-FDG PET/CT) metabolic parameters are prognostic indicators in several neoplasms. This study aimed to evaluate the prognostic value of the maximum and average standardized uptake value (SUVmax and SUVavg), metabolic tumor value (MTV), and total lesion glycolysis (TLG) measured in the primary tumor and suspicious lymph nodes preneoadjuvant therapy in patients submitted to surgical resection for esophageal cancer.MethodsA cohort of 113 patients with esophageal cancer who performed F-18-FDG PET/CT preneoadjuvant therapy was assessed. The association of the SUV, MTV, and TLG measured in the primary tumor and in the suspicious lymph nodes with the overall survival was assessed. It was also analyzed other potentially confounding variables such as age, sex, clinical stage, and histologic subtype. The analyses were performed using Kaplan-Meier curve, log-rank test, and Cox regression.ResultsThe univariate analyses showed that the MTV and TLG in the primary tumor, the SUV in the suspicious lymph nodes, the age, the histologic subtype, and the clinical stage were associated with survival after surgery (P