Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord.
Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord.
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DOI：
10.1038/s41467-020-20703-1
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发表时间：
2021-01-19
影响因子：
16.6
通讯作者：
Capogrosso M
中科院分区：
文献类型：
--
作者：
Greiner N;Barra B;Schiavone G;Lorach H;James N;Conti S;Kaeser M;Fallegger F;Borgognon S;Lacour S;Bloch J;Courtine G;Capogrosso M
腰骶感觉运动回路的硬膜外电刺激（EES）可改善脊髓损伤（SCI）动物和人类的腿部运动控制。上肢运动控制涉及位于颈脊髓中的类似回路，这表明EES也可以改善四肢瘫痪后的手臂和手部运动。然而，颈部EES选择性调节特定上肢运动核团的能力仍不清楚。在这里，我们结合了猕猴颈脊髓的计算模型与实验，探索与EES上肢运动神经元募集的机制，并表征颈部接口的选择性。我们发现，外侧电极产生的直接激活的感觉传入介导的手臂运动神经元的节段性招聘，肌肉对EES的反应在运动过程中调制。术中记录表明人类在休息时具有类似的特性。这些建模和实验结果可以应用于神经技术的发展，旨在改善四肢瘫痪的人类手臂和手的控制。硬膜外电刺激（EES）在脊髓损伤后参与手臂肌肉和改善运动的有效性仍不清楚。在这里，作者研究了EES如何通过将计算建模与非人类灵长类动物的实验相结合来招募上肢运动神经元。
Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting that EES could also improve arm and hand movements after quadriplegia. However, the ability of cervical EES to selectively modulate specific upper-limb motor nuclei remains unclear. Here, we combined a computational model of the cervical spinal cord with experiments in macaque monkeys to explore the mechanisms of upper-limb motoneuron recruitment with EES and characterize the selectivity of cervical interfaces. We show that lateral electrodes produce a segmental recruitment of arm motoneurons mediated by the direct activation of sensory afferents, and that muscle responses to EES are modulated during movement. Intraoperative recordings suggested similar properties in humans at rest. These modelling and experimental results can be applied for the development of neurotechnologies designed for the improvement of arm and hand control in humans with quadriplegia. The efficacy of epidural electrical stimulation (EES) to engage arm muscles and improve movement after spinal cord injury is still unclear. Here, the authors investigated how EES can recruit upper-limb motor neurons by combining computational modelling with experiments in non-human primates.
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脊髓刺激必须保留本体感受，以使脊髓损伤的人类运动。
影响因子：
25
作者：
Formento E;Minassian K;Wagner F;Mignardot JB;Le Goff-Mignardot CG;Rowald A;Bloch J;Micera S;Capogrosso M;Courtine G
通讯作者：
Courtine G
影响因子：
4
作者：
Capogrosso, Marco;Gandar, Jerome;Courtine, Gregoire
通讯作者：
Courtine, Gregoire
影响因子：
7.7
作者：
Chandrasekaran, Santosh;Nanivadekar, Ameya C.;Fisher, Lee E.
通讯作者：
Fisher, Lee E.
影响因子：
5.3
作者：
Capogrosso, Marco;Wenger, Nikolaus;Micera, Silvestro
通讯作者：
Micera, Silvestro
影响因子：
14.8
作者：
Capogrosso, Marco;Wagner, Fabien B.;Courtine, Gregoire
通讯作者：
Courtine, Gregoire