Sodium, arterial stiffness, and cardiovascular mortality in hypertensive rats
Sodium, arterial stiffness, and cardiovascular mortality in hypertensive rats
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DOI：
10.1016/j.amjhyper.2006.09.002
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发表时间：
2007-03-01
影响因子：
3.2
通讯作者：
Lacolley, Patrick
中科院分区：
文献类型：
--
作者：
Mercier, Nathalie;Labat, Carlos;Lacolley, Patrick
背景资料：我们研究了早期高盐饮食（HSD）和血管紧张素II I型（ATI）受体拮抗剂缬沙坦（瓦尔）对存活的自发性高血压大鼠（SHR）死亡率和颈动脉扩张性的影响。方法：HSD早期（出生后4周）或晚期（10周）开始，持续到20周龄，并与正常盐饮食（NSD）组进行比较。结果：安慰剂组早期HSD大鼠死亡率为86%，瓦尔-3 mg组早期HSD大鼠死亡率为70%，瓦尔-30 mg组早期HSD大鼠死亡率为35%，安慰剂组晚期HSD大鼠死亡率为13%。与NSD相比，早期HSD和晚期HSD安慰剂组的平均动脉压（MAP）较高。除早期HSD组外，瓦尔-30 mg可降低所有组的MAP。晚期HSD安慰剂组的MAP扩张性（操作扩张性）低于NSD安慰剂组。瓦尔-30 mg可增加NSD组的扩张性。瓦尔对HSD晚期和早期组无影响。手术扩张性与MAP和盐呈负相关，与瓦尔治疗呈正相关。所有接受HSD的动物表现出较高的等压扩张性在早期HSD比在晚期HSD组和一个较小的扩张性在大鼠治疗瓦尔.Conclusions：我们的研究结果表明，管理早期HSD在SHR与高死亡率，保护作用的瓦尔，增加寿命，和增加水平的等压扩张性。HSD组的存活率表明血管紧张素II在盐诱导的心血管死亡率中的直接作用。这一作用与MAP相关，与颈动脉僵硬度的变化无关。
Background: We examined the effects of early high salt diet (HSD) and angiotensin II type I (ATI) receptor antagonist valsartan (Val) on mortality and carotid distensibility in surviving spontaneously hypertensive rats (SHRs).Methods: The HSD was initiated either early (week 4 after birth) or late (week 10), continued until 20 weeks of age, and compared to normal salt diet (NSD) groups. Valsartan was given from the fourth week after birth.Results: Eighty-six percent of the rats died in early HSD on placebo, 70% in early HSD on Val-3 mg, 35% in early HSD on Val-30 mg, and 13% in late HSD on placebo. Mean arterial pressure (MAP) was higher in the early HSD and late HSD groups on placebo compared with NSD. The Val-30 mg reduced MAP in all except early HSD groups. Distensibility at MAP (operational distensibility) was lower in late HSD on placebo than in NSD placebo groups. The Val-30 mg increased distensibility in NSD groups. There was no effect of Val in late HSD and early HSD groups. Operational distensibility was negatively correlated with MAP and salt and positively correlated with Val treatment. All animals receiving HSD showed a higher isobaric distensibility in early HSD than in late HSD groups and a smaller distensibility in rats treated with Val.Conclusions: Our results showed that administration of early HSD in SHR was associated together with a high mortality, a protective action of Val that increased longevity, and an increased level of isobaric distensibility. Survival in HSD groups suggest a direct role of angiotensin II in salt-induced cardiovascular mortality. This role is associated with MAP independent of changes in carotid stiffness.