Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice
Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice
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DOI：
10.1111/j.1749-6632.1997.tb52356.x
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发表时间：
1997-01-01
期刊：
影响因子：
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通讯作者：
Hen, R
中科院分区：
文献类型：
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作者：
Brunner, D;Hen, R
虽然冲动性的概念在人类和动物成瘾、暴力攻击和暴力自杀的研究中被证明是有用的，并且被认为是人类行为的重要组成部分，但很少有研究来理解潜在的心理生物学机制。我们探索冲动的概念及其与神经递质5-羟色胺的攻击性行为和行为的背景下与正强化使用敲除小鼠，缺乏一个5-羟色胺受体，5-HT 1B受体。与相应的野生型对照组相比，这种基因敲除小鼠表现出更多的冲动性攻击，更快地获得可卡因自我给药，并且喝更多的酒精。我们发现，这些小鼠的冲动特征是不是由于认知功能的变化：在一个认知任务，涉及一个小的立即和一个更大的更延迟的奖励之间的选择，敲除小鼠表现出完整的选择和计时能力和良好的歧视奖励金额。因此，这种小鼠可能证明是成瘾和运动冲动的动物模型。
Although the concept of impulsivity has proved useful in human and animal studies of addiction, violent aggression, and violent suicide, and has been recognized as an important component of human behavior, little research has been done to understand the underlying psychobiological mechanisms. We explore the concept of impulsivity and its relation with the neurotransmitter serotonin in the context of aggressive behavior and behavior associated with positive reinforcement using a knockout mouse that lacks one of the serotonin receptors, the 5-HT1B receptor. This knockout mouse shows more impulsive aggression, acquires cocaine self-administration faster, and drinks more alcohol than the corresponding wild-type control. We show that the impulsive characteristics of these mice are not due to change in cognitive functions: in a cognitive task involving a choice between a small immediate one and a larger more delayed reward, knockout mice showed intact choice and timing capabilities and good discrimination of reward amounts. Thus, this mouse may prove an animal model of addiction and motor impulsivity.