PLASMA AMINO-ACIDS IN APPROPRIATE-FOR-GESTATIONAL-AGE AND SMALL-FOR-GESTATIONAL-AGE FETUSES
PLASMA AMINO-ACIDS IN APPROPRIATE-FOR-GESTATIONAL-AGE AND SMALL-FOR-GESTATIONAL-AGE FETUSES
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DOI：
10.1016/0002-9378(89)90670-4
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发表时间：
1989-11-01
影响因子：
9.8
通讯作者：
EVANS, MI
中科院分区：
文献类型：
--
作者：
ECONOMIDES, DL;NICOLAIDES, KH;EVANS, MI
采用脐静脉穿刺法测定28例小于胎龄胎儿的血浆氨基酸谱，并与62例小于胎龄胎儿的血浆氨基酸谱进行比较。在适合妊娠的年龄组中，胎儿水平与母体水平显著相关，但高于母体水平，这表明胎盘积极转运氨基酸。小于胎龄组胎儿血浆必需氨基酸浓度和母胎比降低，且与胎儿低氧血症程度显著相关。有一个可变的反应（例如，丙氨酸增加，而丝氨酸和酪氨酸减少）涉及非必需氨基酸。在脐静脉低氧血症的血浆中的非必需/必需氨基酸的比例增加，和母体血浆中的必需和非必需氨基酸的浓度增加。这些结果表明，在子宫胎盘功能不全有宫内饥饿。
The fetal plasma amino acid proflies of 28 small-for-gestational-age fetuses were established in umbilical venous blood samples obtained by cordocentesis and the values were compared with those of 62 appropriate-for-gestational age fetuses. In the appropriate-for-gestatational-age group fetal levels were significantly correlated with but were higher than the maternal levels, which indicates that amino acids are actively transported by the placenta. In the small-for-gestational-age group, the fetal plasma concentration and the fetomaternal ratio of essential amino acids was decreased and this decrease was significantly correlated with the degree of fetal hypoxemia. There was a variable response (.e.g, alanine was increased, whereas serine and tyrosine were decreased) involved with nonessential amino acids. In umbilical venous hypoxemia the plasma ratio of nonessential/essential amino acids were increased, and the maternal plasma concentrations of both essential and nonessential amino acids were increased. These findings suggest that in uteroplacental insufficiency there is intrauterine starvation.