Divergent nitric oxide bioavailability in men and women with sickle cell disease
Divergent nitric oxide bioavailability in men and women with sickle cell disease
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DOI：
10.1161/01.cir.0000044943.12533.a8
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发表时间：
2003-01-21
期刊：
影响因子：
37.8
通讯作者：
Cannon, RO
中科院分区：
文献类型：
--
作者：
Gladwin, MT;Schechter, AN;Cannon, RO
背景--尽管在动脉血管疾病中内皮细胞一氧化氮（NO）生物利用度降低已被证实，但在镰状细胞病中该系统的完整性仍不确定。方法和结果--我们测量了21名镰状细胞病患者的前臂血流（血红蛋白SS基因型）和18名黑人对照受试者在动脉内输注乙酰胆碱，硝普钠，和NO合酶抑制剂NG-单甲基-L-精氨酸（L-NMMA）。血管内皮依赖性舒张，通过乙酰胆碱输注引起的血流增加百分比来衡量，显著高于对照组（患者252 +/- 37%，对照组134-124%; P
Background-Although reduced endothelial nitric oxide (NO) bioavailability has been demonstrated in arteriosclerotic vascular disease, the integrity of this system in sickle cell disease remains uncertain.Methods and Results-We measured forearm blood flow in 21 patients with sickle cell disease (hemoglobin SS genotype) and 18 black control subjects before and after intra-arterial infusions of acetylcholine, nitroprusside, and the NO synthase inhibitor NG-monomethyl-L-arginine (L-NMMA). Endothelium-dependent vasodilation, measured by the percent increase in flow induced by acetylcholine infusion, was significantly greater than in controls (252 +/- 37% for patients versus 134-124% for controls; P