Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index.
Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index.
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DOI：
10.1017/s095457941500098x
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发表时间：
2015-11
影响因子：
3.3
通讯作者：
Rogosch FA
中科院分区：
文献类型：
--
作者：
Thibodeau EL;Cicchetti D;Rogosch FA
一个模型研究了越来越多的虐待亚型经历的反社会行为的影响，介导的冲动和调节多巴胺能基因型的多基因指数，进行了调查。一个非裔美国人的儿童样本（N = 1012，M年龄= 10.07），并没有虐待的历史参加。指标的侵略性，犯罪，破坏性的同伴行为，从同行和辅导员评定的措施，形成一个潜在的变量的反社会行为，冲动进行了评估，辅导员报告。在四个多巴胺能基因（DRD 4，DRD 2，DAT 1，和COMT）赋予环境敏感性增加的五种基因型组合成一个多基因指数。使用SEM，第一阶段，适度的中介模型进行了评估。年龄和性别作为协变量输入，既作为主效应，又与虐待和基因指数相互作用。模型拟合良好，χ2（32，N =1012）= 86. 51，p<0.001; CFI = 0.982; TLI = 0.977; RMSEA = 0.041; SRMR = 0.022。虐待亚型对反社会行为的影响部分由冲动性介导（β= 0.173，p<0.001），并且这些关系由分化的多巴胺能基因型的数量调节。具体而言，一个显着的GxE相互作用（B = 0.016，p = 0.013）表明，虐待和冲动之间的关系是更强的儿童表现出更多的分化基因型，从而加强反社会行为的冲动的中介作用。这些研究结果阐明了虐待儿童发展反社会行为的早期迹象的方式，以及在虐待儿童的背景下，冲动控制适应不良的遗传机制。
A model examining the effects of an increasing number of maltreatment subtypes experienced on antisocial behavior, as mediated by impulsivity and moderated by a polygenic index of dopaminergic genotypes, was investigated. An African American sample of children (N = 1012, M age = 10.07) with and without maltreatment histories participated. Indicators of aggression, delinquency, and disruptive peer behavior were obtained from peer and counselor rated measures to form a latent variable of antisocial behavior; impulsivity was assessed by counselor report. Five genotypes in four dopaminergic genes (DRD4, DRD2, DAT1, and COMT) conferring heightened environmental sensitivity were combined into one polygenic index. Using SEM, a first-stage, moderated-mediation model was evaluated. Age and sex were entered as covariates, both as main effects and in interaction with maltreatment and the gene index. The model had excellent fit: χ2(32, N =1012) = 86..51, p<0.001; CFI = 0.982; TLI = 0.977; RMSEA = 0.041; SRMR = 0.022. The effect of maltreatment subtypes on antisocial behavior was partially mediated by impulsivity (β= 0.173, p<0.001), and these relations were moderated by the number of differentiating dopaminergic genotypes. Specifically, a significant GxE interaction (b = 0.016, p = 0.013) indicated that the relation between maltreatment and impulsivity was stronger as children evinced more differentiating genotypes, thereby strengthening the mediational effect of impulsivity on antisocial behavior. These findings elucidate the manner by which maltreated children develop early signs of antisocial behavior, and the genetic mechanisms involved in greater vulnerability for maladaptation in impulse-control within context of child maltreatment.