Age-related changes in the TRB and IGH repertoires in healthy adult males and females
Age-related changes in the TRB and IGH repertoires in healthy adult males and females
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健康成年男性和女性 TRB 和 IGH 库与年龄相关的变化
DOI：
10.1016/j.imlet.2021.10.002
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发表时间：
2021-10-19
影响因子：
4.4
通讯作者：
Wang, Zhanhui
中科院分区：
文献类型：
--
作者：
Gong, Mingxing;Li, Xueying;Wang, Zhanhui
一个多样化的免疫库能够识别生命中遇到的大量外来抗原。衰老对免疫系统有着深远的影响。然而，是否连续的年龄相关的变化，在免疫库中的性别之间的差异尚不清楚。本研究通过分析361名健康成年人的T细胞受体β链（TRB）和免疫球蛋白重链（IGH）序列，揭示了衰老过程中按性别分层的免疫谱系特征。在男性和女性的整个生命周期中观察到类似的变化，而年龄亚组分析显示TRB和IGH库中的性别特异性签名。在TRB方面，在男性中，库丰富度和均匀度分别在32岁和45岁之前略有增加，之后急剧下降。有趣的是，在女性中，它们在57岁左右显著下降，随后在83岁之前经历一个稳定阶段。虽然IGH库均匀性增加显着随着年龄的增长，在两种性别，丰富度随年龄的男性显着下降，但在女性中保持稳定。此外，IGH CDR 3的平均长度随年龄增加而增加。总之，这些研究结果提供了基本的见解，适应性免疫的性别差异的机制。
A diverse immune repertoire is capable of recognizing the enormous universe of foreign antigens encountered over life. Aging has a profound impact on the immune repertoires. However, whether continuous age-related changes in the immune repertoires differ between sexes is unclear. In this study, the characteristics of immune repertoires stratified by sex during aging are deciphered by analyzing T-cell receptor beta-chain (TRB) and immunoglobulin heavy chain (IGH) sequences in 361 healthy adults. A similar change was observed between males and females across their lifespan, whereas age-subgroup analysis revealed sex-specific signatures in TRB and IGH repertoires. In regard to TRB, in males, repertoire richness and evenness increases slightly before the age of 32 years and 45 years respectively, and decreases sharply thereafter. Intriguingly, in females, they decrease significantly until around the age 57 years old, and subsequently undergo a stable stage up to the age of 83 years. Although IGH repertoire evenness increases significantly with age in both sexes, richness decreases significantly with age in males but remains stable in females. Moreover, average length of IGH CDR3 increases with age. In conclusion, these findings provide fundamental insights into the mechanisms underlying sex differences in adaptive immunity.