Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis
Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis
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DOI：
10.1016/j.jcrs.2010.06.067
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发表时间：
2010-12-01
影响因子：
2.8
通讯作者：
Hersh, Peter S.
中科院分区：
文献类型：
--
作者：
Greenstein, Steven A.;Fry, Kristen L.;Hersh, Peter S.
目得：通过Scheimpflug成像和裂隙灯生物显微镜测量圆锥角膜或角膜扩张患者激光原位角膜磨镶术后胶原交联（CXL）相关角膜混浊的自然史。对照组仅接受核黄素治疗，不进行上皮清创。为了客观地测量CXL相关的角膜混浊，使用Scheimpflug成像测量角膜密度，并分析混浊随时间的变化。使用临床医生确定的裂隙灯雾度进行了类似的分析。CXL相关角膜混浊与术后outcome.Results的相关性进行了分析：平均术前角膜密度测定为14.9 +/- 1.93（SD）（Pentacam Scheimpflug密度测定单位）。密度测定在1个月时达到峰值（平均23.4 ± 4.40; P
PURPOSE: To determine the natural history of collagen crosslinking (CXL)-associated corneal haze measured by Scheimpflug imagery and slitlamp biomicroscopy in patients with keratoconus or ectasia after laser in situ keratomileusis.SETTING: Cornea and refractive surgery subpecialty practice, United States.DESIGN: Prospective randomized controlled clinical trial.METHODS: The treatment group received ultraviolet-A/riboflavin CXL therapy. The control group received riboflavin alone without epithelial debridement. To objectively measure CXL-associated corneal haze, corneal densitometry using Scheimpflug imagery was measured and the changes in haze were analyzed over time. A similar analysis was performed using clinician-determined slitlamp haze. Correlation of CXL-associated corneal haze with postoperative outcomes was analyzed.RESULTS: The mean preoperative corneal densitometry was 14.9 +/- 1.93 (SD) (Pentacam Scheimpflug densitometry units). Densitometry peaked at 1 month (mean 23.4 +/- 4.40; P