A preferential increase in the extrastriate response to signals of danger
A preferential increase in the extrastriate response to signals of danger
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DOI：
10.1016/s1053-8119(03)00085-5
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发表时间：
2003-08-01
期刊：
影响因子：
5.7
通讯作者：
Phillips, ML
中科院分区：
文献类型：
--
作者：
Surguladze, SA;Brammer, MJ;Phillips, ML
本研究检查了9名右撇子健康个体的神经反应，同时他们在四个事件相关的功能磁共振成像实验中观察了四种情绪（恐惧，厌恶，快乐和悲伤）的温和和强烈的表达，并与中性面孔进行了对比。正交多项式趋势分析显示，梭状纹外皮层对所有四种情绪表达强度增加的反应呈显著线性增加，对恐惧和厌恶的反应强度增加明显大于对快乐和悲伤的反应强度增加，对悲伤的反应在另一个纹外区域呈显著线性减少。杏仁核被高强度的恐惧表情激活，这与先前的研究结果一致，也被低强度但不是高强度的悲伤表情激活。海马、前额叶和壳核分别对恐惧、厌恶和幸福强度的增加作出了显著的线性增加。相反，海马和壳核反应的显着线性下降发生悲伤的强度增加。我们提供了第一个示范的差异增加的纹外和边缘系统的反应，增加的危险信号比那些其他的情绪，和显着减少，这些反应的信号增加的悲伤在别人。我们认为，这种不同类型的情绪信号的反应模式允许优先方向的视觉注意的信号迫在眉睫的危险比其他，不太突出的情绪刺激。(C)2003 Elsevier Science（美国）。All rights reserved.
This study examined neural responses in nine right-handed healthy individuals while they viewed mild and intense expressions of four emotions (fear, disgust, happiness, and sadness) contrasted with neutral faces in four event-related functional magnetic resonance imaging experiments. Orthogonal polynomial trend analysis revealed a significant linear increase in the fusiform extrastriate cortical response to increasing intensities of all four emotional expressions, which was significantly greater to increasing intensities of fear and disgust than happiness and sadness, and a significant linear decrease in response to sadness in another extrastriate region. The amygdala was activated by high-intensity fearful expressions, consistent with findings from previous studies, and by low- but not high-intensity sad expressions. Significant linear increases in response to increasing intensities of fear, disgust, and happiness occurred within the hippocampus, anterior insula, and putamen, respectively. Conversely, significant linear decreases in hippocampal and putamen responses occurred to increasing intensities of sadness. We provide the first demonstration of differential increases in extrastriate and limbic responses to signals of increasing danger than to those of other emotions, and significant decreases in these responses to signals of increasing sadness in others. We suggest that this differential pattern of response to different categories of emotional signals allows the preferential direction of visual attention to signals of imminent danger than to other, less-salient emotional stimuli. (C) 2003 Elsevier Science (USA). All rights reserved.