Clinicopathologic studies on perineural invasion of bile duct carcinoma.
Clinicopathologic studies on perineural invasion of bile duct carcinoma.
复制标题
胆管癌神经周围侵犯的临床病理学研究。
DOI：
10.1097/00000658-199204000-00007
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发表时间：
1992
影响因子：
9
通讯作者：
S. Shionoya
中科院分区：
文献类型：
--
作者：
Md. Mukhlesur Rahman Bhuiya;Yuji Nimura;J. Kamiya;Satoshi Kondo;Shinji Fukata;N. Hayakawa;S. Shionoya
为探讨神经侵袭对胆管癌的临床意义，对70例胆管癌手术切除患者进行了临床病理研究。切除标本中神经侵犯的总发生率为81.4%。神经侵袭与肿瘤的部位、大小、淋巴结转移无关。然而，在大体类型、微观类型、侵犯深度和神经周围侵犯之间观察到显著的相关性。神经周围侵袭指数(PNI)定义为癌侵袭神经纤维数与有无癌侵袭神经纤维总数之比。肿瘤中心的神经侵袭指数明显高于肿瘤的近端和远端(p<0.001)。有神经侵袭者的5年生存率(P<0.05)明显低于无神经侵袭者(67%比32%)。
To elucidate the clinical significance of perineural invasion on bile duct cancer, a clinicopathologic study was performed on 70 resected patients with bile duct carcinoma. The overall incidence of perineural invasion in the resected specimen was 81.4%. There seemed to be no correlation between perineural invasion and site, size of the tumor, and lymph node metastasis. A significant correlation was observed, however, between macroscopic type, microscopic type, depth of invasion, and perineural invasion. Perineural invasion index (PNI) was defined as the ratio between the number of nerve fibers invaded by cancer and the total number of nerve fibers with and without cancer invasion. Perineural invasion index was significantly higher at the center compared with the proximal and distal part of the tumor (p less than 0.001). The 5-year survival rate for patients with perineural invasion was significantly lower (p less than 0.05) than that for those without perineural invasion (67% versus 32%).