Classifying Cancers Based on T-cell Infiltration and PD-L1.
Classifying Cancers Based on T-cell Infiltration and PD-L1.
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DOI：
10.1158/0008-5472.can-15-0255
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发表时间：
2015-06-01
期刊：
影响因子：
11.2
通讯作者：
Smyth MJ
中科院分区：
文献类型：
--
作者：
Teng MW;Ngiow SF;Ribas A;Smyth MJ
在接下来的十年里，癌症免疫疗法可能成为许多癌症的主要治疗支柱。在癌症中发现了许多免疫细胞类型，以及对癌症的免疫反应的许多组件。因此，肿瘤有许多策略来逃避免疫反应。根据肿瘤浸润性淋巴细胞的存在和程序性死亡配体1(PD-L1)的表达，已经提出了四种不同类型的肿瘤微环境。我们回顾了这一分层和一系列结果中的最新结果，这些结果揭示了合理设计基于肿瘤免疫学的理想癌症联合治疗的新方法。
Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus the tumor has many strategies to evade an immune response. It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor infiltrating lymphocytes and programmed death-ligand 1 (PD-L1) expression. We review this stratification and the latest in a series of results that shed light on new approaches for rationally designing ideal combination cancer therapies based on tumor immunology.