Endogenous Action Selection Processes in Dorsolateral Prefrontal Cortex Contribute to Sense of Agency: A Meta-Analysis of tDCS Studies of 'Intentional Binding'
Endogenous Action Selection Processes in Dorsolateral Prefrontal Cortex Contribute to Sense of Agency: A Meta-Analysis of tDCS Studies of 'Intentional Binding'
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DOI：
10.1016/j.brs.2016.01.005
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发表时间：
2016-05-01
影响因子：
7.7
通讯作者：
Haggard, Patrick
中科院分区：
文献类型：
--
作者：
Khalighinejad, Nima;Di Costa, Steven;Haggard, Patrick
背景：代理感是一种对自己的行为及其后果进行控制的体验。前额叶皮质在动作控制和意识方面的作用尚不清楚。目的/假设：考虑到背外侧前额叶皮质(DLPFC)在动作选择中的作用，我们预测当参与者在多个动作之间进行选择时，DLPFC可能有助于提高代理感。方法：我们通过操纵与动作选择和动作结果相关的一系列任务参数，在参与者暴露于左侧DLPFC的tdcs刺激下进行了一系列实验。我们使用意向约束效应来测量自愿行为与其结果之间的时间关联，作为代理意识的内隐测量。结果：我们的原始数据的固定效应荟萃分析显示，我们的原始数据有向正面tdcs发展的趋势，同时我们的实验之间存在相当大的异质性。根据参与者是否在可供选择的行为之间进行内源性选择，将实验划分为研究的子集，可以解释这种异质性的71%。在涉及内源性动作选择的研究子集中，DLPFC的阳极刺激增加了动作对音调的时间绑定，而在其他研究中则没有。结论：当参与者在多个动作之间进行选择时，DLPFC可能有助于提高代理感。这种增强的对自愿行为的控制感可能与观察到的额叶tdcs对抑郁症的疗效有关。(C)2016年提交人。由爱思唯尔公司出版。
Background: Sense of agency is the experience of being in control of one's own actions and their consequences. The role of frontal cortex in this aspect of action control and awareness remains unclear.Objective/hypothesis: Given the role of dorsolateral prefrontal cortex (DLPFC) in action selection, we predicted that DLPFC may contribute to sense of agency when participants select between multiple actions.Methods: We performed a series of experiments by manipulating a range of task parameters related to action selection and action outcomes while participants were exposed to tDCS stimulation of the left DLPFC. We measured the temporal association between a voluntary action and its outcome using the intentional binding effect, as an implicit measure of sense of agency.Results: Fixed-effect meta-analysis of our primary data showed a trend towards a frontal tDCS, together with considerable heterogeneity between our experiments. Classifying the experiments into subsets of studies, according to whether participants endogenously selected between alternative actions or not, explained 71% of this heterogeneity. Anodal stimulation of DLPFC increased the temporal binding of actions towards tones in the subset of studies involving endogenous action selection, but not in the other studies.Conclusions: DLPFC may contribute to sense of agency when participants selected between multiple actions. This enhanced feeling of control over voluntary actions could be related to the observed therapeutic effects of frontal tDCS in depression. (C) 2016 The Authors. Published by Elsevier Inc.