Vitamin E. Neurochemistry and implications for neurodegeneration in Parkinson's disease.
Vitamin E. Neurochemistry and implications for neurodegeneration in Parkinson's disease.
复制标题
维生素 E。神经化学及其对帕金森病神经变性的影响。
DOI：
10.1111/j.1749-6632.1992.tb17092.x
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发表时间：
1992
影响因子：
5.2
通讯作者：
Vatassery,GT
中科院分区：
文献类型：
--
作者：
Vatassery,GT
最近，补充维生素E在改善神经系统疾病中的潜在治疗用途引起了极大的兴趣。尽管许多研究提供了令人鼓舞的结果，但任何有益效果的机制仍然难以捉摸。实验研究表明，损伤前组织中存在高水平的维生素E对于生物学功效是必不可少的，因为损伤后给予维生素通常是无效的。目前尚不清楚这种现象的原因。一些剩余的研究领域包括维生素E与其他生物抗氧化剂物质（如维生素C和巯基化合物）的生物化学相互作用;不同分子形式的生育酚（如三烯酚和各种光学异构体）的相对效力;以及最有效的生育酚分子的最佳剂量和给药方式。未来对这些和其他主题的研究将更多地揭示维生素E在神经退行性疾病中的有效应用。
Recently there has been a great deal of interest in the potential therapeutic use of supplemental vitamin E in amelioration of diseases of the nervous system. Even though many studies have provided encouraging results, the mechanism of any beneficial effect remains elusive. Experimental studies suggest that the presence of high levels of vitamin E in tissues prior to injury is essential for biological efficacy because administration of the vitamin after insult is often ineffective. The rationale for this phenomenon is unknown at present. Some of the remaining areas of investigation include the biochemical interaction of vitamin E with other biological antioxidant substances such as vitamin C and sulfhydryl compounds; the relative potencies of different molecular forms of tocopherols, such as trienols and various optical isomers; and the optimal dosage and mode of administration of the most potent tocopherol molecule. Future research on these and other topics will shed more light on the effective use of vitamin E in neurodegeneration.