Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction.
Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction.
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DOI：
10.4331/wjbc.v1.i5.69
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发表时间：
2010-05-26
期刊：
影响因子：
--
通讯作者：
Uede, Toshimitsu
中科院分区：
文献类型：
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作者：
Matsui, Yutaka;Morimoto, Junko;Uede, Toshimitsu
心肌梗死（MI）发作后，左心室（LV）经历一系列分子、细胞和细胞外反应，导致LV壁变薄、扩张和功能障碍。这些LV形状、大小和功能的动态变化称为心脏重塑。如果MI后心脏愈合不正常，可能导致心脏破裂或适应不良的心脏重塑，如进一步的LV扩张和功能障碍，最终导致死亡。虽然在这个心脏愈合过程中的精确分子机制尚未完全阐明，但这个过程是由细胞与其周围的细胞外基质（ECM）蛋白的相互作用严格协调的。ECM的成分包括基本结构蛋白如胶原蛋白、弹性蛋白和特化蛋白如纤连蛋白、蛋白聚糖和基质细胞蛋白。基质细胞蛋白是一类非结构性分泌蛋白，可能通过与细胞表面受体、其他基质蛋白以及可溶性细胞外因子如生长因子和细胞因子直接结合而发挥调节功能。这一小组蛋白质包括骨桥蛋白、血小板反应蛋白-1/2、腱生蛋白、骨膜蛋白和分泌蛋白、酸性和富含半胱氨酸，在正常成人组织中显示低水平表达，但在伤口愈合和组织重塑（包括MI）期间显著上调。本文就基质细胞蛋白在心肌梗死后心脏组织愈合和重塑中的调控作用作一综述。
After onset of myocardial infarction (MI), the left ventricle (LV) undergoes a continuum of molecular, cellular, and extracellular responses that result in LV wall thinning, dilatation, and dysfunction. These dynamic changes in LV shape, size, and function are termed cardiac remodeling. If the cardiac healing after MI does not proceed properly, it could lead to cardiac rupture or maladaptive cardiac remodeling, such as further LV dilatation and dysfunction, and ultimately death. Although the precise molecular mechanisms in this cardiac healing process have not been fully elucidated, this process is strictly coordinated by the interaction of cells with their surrounding extracellular matrix (ECM) proteins. The components of ECM include basic structural proteins such as collagen, elastin and specialized proteins such as fibronectin, proteoglycans and matricellular proteins. Matricellular proteins are a class of non-structural and secreted proteins that probably exert regulatory functions through direct binding to cell surface receptors, other matrix proteins, and soluble extracellular factors such as growth factors and cytokines. This small group of proteins, which includes osteopontin, thrombospondin-1/2, tenascin, periostin, and secreted protein, acidic and rich in cysteine, shows a low level of expression in normal adult tissue, but is markedly upregulated during wound healing and tissue remodeling, including MI. In this review, we focus on the regulatory functions of matricellular proteins during cardiac tissue healing and remodeling after MI.