Ensemble of deep convolutional neural networks based multi-modality images for Alzheimer's disease diagnosis
Ensemble of deep convolutional neural networks based multi-modality images for Alzheimer's disease diagnosis
复制标题
基于多模态图像的深度卷积神经网络集成，用于阿尔茨海默病诊断
DOI：
10.1049/iet-ipr.2019.0617
复制
发表时间：
2020-02-07
影响因子：
2.3
通讯作者：
Xu, Mingchang
中科院分区：
文献类型：
--
作者：
Fang, Xusheng;Liu, Zhenbing;Xu, Mingchang
Alzheimer's disease (AD) is one of the most common progressive neurodegenerative diseases. Structural magnetic resonance imaging (MRI) would provide abundant information on the anatomical structure of human organs. Fluorodeoxy-glucose positron emission tomography (PET) obtains the metabolic activity of the brain. Previous studies have demonstrated that multi-modality images could contribute to improve diagnosis of AD. However, these methods need to extract the handcrafted features that demand domain specific knowledge and image processing stage is time consuming. In order to tackle these problems, in this study, the authors propose a novel framework that ensembles three state-of-the-art deep convolutional neural networks (DCNNs) with multi-modality images for AD classification. In detail, they extract some slices from each subject of each modality, and every DCNN generates a probabilistic score for the input slices. Furthermore, a `dropout' mechanism is introduced to discard low discrimination slices of the category probabilities. Then average reserved slices of each subject are acquired as a new feature. Finally, they train the Adaboost ensemble classifier based on single decision tree classifier with the MRI and PET probabilistic scores of each DCNN. Evaluations on Alzheimer's Disease Neuroimaging Initiative database show that the proposed algorithm has better performance compared to existing method, the algorithm proposed in this study significantly improved the classification accuracy.
