Expectation and dopamine release:: Mechanism of the placebo effect in Parkinson's disease
Expectation and dopamine release:: Mechanism of the placebo effect in Parkinson's disease
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DOI：
10.1126/science.1060937
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发表时间：
2001-08-10
期刊：
影响因子：
56.9
通讯作者：
Stoessl, AJ
中科院分区：
文献类型：
--
作者：
de la Fuente-Fernández, R;Ruth, TJ;Stoessl, AJ
长期以来，安慰剂的功效一直被认为可以改善许多医疗状况，如帕金森氏病(PID)。然而，人们对安慰剂效应背后的机制知之甚少。利用正电子发射断层扫描测量的内源性多巴胺竞争[C-11]拉氯普利结合的能力，我们提供了体内证据，证明内源性多巴胺在帕金森病患者纹状体对安慰剂的反应显著释放。我们的发现表明，帕金森病的安慰剂效应是强大的，并通过激活受损的黑质纹状体多巴胺系统来调节。
The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PID). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [C-11]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PID, patients in response to placebo. Our findings indicate that the placebo effect in PID is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.