Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: support for a neural sensitization model.
Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: support for a neural sensitization model.
复制标题
中年女性的早期生活压力、消极的父亲关系和化学不耐受：支持神经敏化模型。
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Elizabeth E. Hardin
中科院分区：
文献类型：
--
作者：
Iris R. Bell;Carol M. Baldwin;L. G. Russek;Gary E. Schwartz;Elizabeth E. Hardin
本研究（ntotal = 35）比较了患有低水平化学物质不耐受（CI组）、抑郁症、无CI的抑郁症（DEP组）和正常人的中年妇女的早期生活压力评分、父母关系和健康状况，特别是体位血压。环境化学物质不耐受是几种有争议的病症的症状，其中女性比例过高，即病态建筑综合征、多种化学物质敏感性、慢性疲劳综合征和纤维肌痛。先前的研究人员假设，CI患者有躯体化障碍、抑郁症、创伤后应激障碍（PTSD）的变体，这些疾病是由童年虐待或有毒物质暴露事件引起的。神经致敏是CI、躯体化障碍、复发性抑郁症和创伤后应激障碍的一种神经行为模型，即宿主对反复间歇性刺激（如药物、化学物质、内源性介质、应激源）的反应（如行为、神经化学）的逐渐放大。女性比男性更容易过敏。边缘和中边缘通路介导中枢神经系统的敏感化。虽然CI组和DEP组都有高水平的生活压力和过去的虐待，但CI组的父系关系最疏远、最弱，边缘躯体功能障碍亚量表得分最高。只有CI组在治疗过程中表现出坐姿血压的敏感性。结合先前的证据，这些数据与某些女性CI的神经致敏模型一致。这一发现可能会对一部分CI女性较差的长期医疗和神经精神健康结果产生影响。后续研究应在特定的CI临床诊断组中检验该模型。
This study (ntotal = 35) compared early life stress ratings, parental relationships, and health status, notably orthostatic blood pressures, of middle-aged women with low-level chemical intolerance (CI group) and depression, depressives without CI (DEP group), and normals. Environmental chemical intolerance is a symptom of several controversial conditions in which women are overrepresented, that is, sick building syndrome, multiple chemical sensitivity, chronic fatigue syndrome, and fibromyalgia. Previous investigators have postulated that people with CI have variants of somatization disorder, depression, posttraumatic stress disorder (PTSD) initiated by childhood abuse or a toxic exposure event. One neurobehavioral model for CI, somatization disorder, recurrent depression, and PTSD is neural sensitization, that is, the progressive amplification of host responses (e.g., behavioral, neurochemical) to repeated intermittent stimuli (e.g., drugs, chemicals, endogenous mediators, stressors). Females are more vulnerable to sensitization than are males. Limbic and mesolimbic pathways mediate central nervous system sensitization. Although both CI and DEP groups had high levels of life stress and past abuse, the CI group had the most distant and weak paternal relationships and highest limbic somatic dysfunction subscale scores. Only the CI group showed sensitization of sitting blood pressures over sessions. Together with prior evidence, these data are consistent with a neural sensitization model for CI in certain women. The findings may have implications for poorer long-term medical as well as neuropsychiatric health outcomes of a subset of women with CI. Subsequent research should test this model in specific clinical diagnostic groups with CI.
DOI：
10.1176/ajp.150.1.83
发表时间：
1993
期刊：
The American journal of psychiatry
影响因子：
--
作者：
R. Yehuda;S. Southwick;J. Krystal;D. Bremner;D. Charney;J. Mason
通讯作者：
R. Yehuda;S. Southwick;J. Krystal;D. Bremner;D. Charney;J. Mason
影响因子：
5.9
作者：
Morrow,LA;Kamis,H;Hodgson,MJ
通讯作者：
Hodgson,MJ
多种化学敏感性患者的嗅觉敏感性、鼻阻力和自主功能。
DOI：
10.1001/archotol.1988.01860240072027
发表时间：
1988
期刊：
Archives of otolaryngology--head & neck surgery
影响因子：
--
作者：
Doty,RL;Deems,DA;Frye,RE;Pelberg,R;Shapiro,A
通讯作者：
Shapiro,A