Increased expression of integrin β-4 in papillary thyroid carcinoma with gross lymph node metastasis
Increased expression of integrin β-4 in papillary thyroid carcinoma with gross lymph node metastasis
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DOI：
10.1046/j.1440-1827.2002.01379.x
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发表时间：
2002-07-01
影响因子：
2.2
通讯作者：
Ikehara, S
中科院分区：
文献类型：
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作者：
Kitajiri, S;Hosaka, N;Ikehara, S
虽然甲状腺乳头状癌患者的预后一般较好，但肉眼淋巴结转移的患者预后较差。为了建立治愈方法，有必要澄清癌症如何进展为肉眼淋巴结转移。粘附分子整合素β-4被认为与许多癌症中的细胞迁移和转移有关。在本研究中，我们采用免疫组织化学方法检测了 65 例人甲状腺乳头状癌中整合素 β-4 的表达。在所有乳头状癌中都发现了整合素β-4的表达，但在少数正常甲状腺细胞中也有表达。有趣的是，整合素β4在淋巴结转移大（大于或等于3cm）的癌中表达显着高于小（≥3cm）淋巴结转移的癌。
Although the prognosis is generally good for patients with papillary thyroid carcinoma, gross nodal metastasis of carcinoma has a poor prognosis. It is necessary to clarify how carcinoma progresses to gross nodal metastasis in order to establish a cure. The adhesion molecule integrin beta-4 is considered to be related to cell migration and metastasis in many carcinomas. In the present study, we examined integrin beta-4 expression in 65 cases of human papillary thyroid carcinoma using immunohistochemical methods. Expression of integrin beta-4 was found in all papillary carcinomas, but in few normal thyrocytes. Interestingly, integrin beta-4 expression in the carcinomas with gross (greater than or equal to3 cm) lymph node metastasis was significantly higher than that in carcinomas with small (