Subcortical arteriosclerotic encephalopathy (Binswanger's type) and cortical infarcts in a young normotensive patient.
Subcortical arteriosclerotic encephalopathy (Binswanger's type) and cortical infarcts in a young normotensive patient.
复制标题
年轻血压正常患者的皮质下动脉硬化性脑病（Binswanger 型）和皮质梗死。
DOI：
10.1136/jnnp.45.5.409
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Thomas Smith
中科院分区：
文献类型：
--
作者：
LA Loizou;JM Jefferson;Thomas Smith
一名49岁、血压正常的男子在经历了一系列中风、缓慢发展的痴呆症和23年的人格改变后去世。CT扫描显示颞枕区皮层和白质大面积梗死，皮质下小梗死，额叶和顶叶白质低衰减。神经病理学检查显示大的皮质梗死和小的皮质下梗死，与影像学表现一致，中央白质变性/脱髓鞘与CT低衰减区一致。基本的潜在病理过程是透明动脉硬化和动脉粥样硬化，弥漫性影响脑内小动脉，少量影响威利斯圈动脉。虽然由于没有高血压，这是常见的，但该综合征发病的年龄非常早，并且存在大面积皮质梗死，本病例说明了皮质下动脉硬化性脑病（Binswanger型）的临床、放射学和神经病理学特征。
A 49-year-old normotensive man died after a series of strokes, slowly evolving dementia and personality change occurring over a period of 23 years. CT scan showed large infarcts involving the cortex and white matter of the temporo-occipital areas, small subcortical infarcts and low attenuation in the white matter of the frontal and parietal lobes. Neuropathological examination revealed large cortical and small subcortical infarcts corresponding to the radiological findings as well as degeneration/demyelination of central white matter corresponding to the areas of low attenuation seen on CT. The basic underlying pathological process was hyaline arteriosclerosis and atheroma which diffusely affected the small intracerebral arteries and to a lesser extent the arteries of the circle of Willis. Though usual because of the absence of hypertension, the very early age at onset of the syndrome and the presence of large cortical infarcts this case illustrates the clinical, radiological and neuropathological features of subcortical arteriosclerotic encephalopathy (Binswanger's type).