Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.
Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.
复制标题
饮食和运动引起的体重减轻对乳腺癌幸存者炎症生物标志物的影响：系统评价和荟萃分析。
DOI：
10.1158/1055-9965.epi-20-1029
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发表时间：
2021-06
期刊：
影响因子：
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通讯作者：
Sturgeon KM
中科院分区：
文献类型：
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作者：
Bruinsma TJ;Dyer AM;Rogers CJ;Schmitz KH;Sturgeon KM
Adiponectin, leptin, and pro- and anti-inflammatory cytokines are implicated in breast cancer risk and recurrence. Weight loss, via the dynamic interplay of energy balance through exercise and/or caloric restriction decreases risk of breast cancer recurrence. We investigated the effects of lifestyle modifications (exercise only, or combined caloric restriction and exercise) on adipokines, IL-2, IL-6, IL-8, IL-10, CRP, and TNF-α biomarkers in breast cancer survivors. Searches were completed in June and July of 2019 to identify randomized controlled trials that met inclusion criteria. Weighted mean difference was calculated using random- or fixed- effects models based on the heterogeneity of the studies. 2501 records were identified with 30 ultimately meeting inclusion criteria of the systematic review. 21 studies provided data suitable for meta-analysis. We observed leptin levels were significantly reduced in the exercise only group compared to sedentary control (WMD −5.66; 95% CI, −11.0 to −0.33, p = 0.04). Leptin may be a primary mediator of exercise–induced improvements in breast cancer recurrence. This is the first review and meta-analysis to examine combined exercise and caloric restriction programs in breast cancer survivors. Future studies should further examine combined programs and their efficacy for altering leptin.
