Alteration of endothelial function markers in women with gestational diabetes and their fetuses.
Alteration of endothelial function markers in women with gestational diabetes and their fetuses.
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DOI：
10.3109/14767058.2012.736564
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Rodgers KE
中科院分区：
文献类型：
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作者：
Mordwinkin NM;Ouzounian JG;Yedigarova L;Montoro MN;Louie SG;Rodgers KE
我们通过对患有妊娠糖尿病 (GDM) 的女性及其胎儿进行试点观察性病例对照研究，测试了以下假设：患有妊娠糖尿病 (GDM) 的女性及其胎儿会表现出内皮一氧化氮合酶 (eNOS) 解偶联、氧化应激和内皮功能障碍标记物的变化，并且这些变化与高血糖水平相关。在患有和不患有 GDM 的妇女分娩时，测量母体和脐带血中可溶性细胞间粘附分子-1 (sICAM-1)、可溶性血管细胞粘附分子-1 (sVCAM-1)、C 反应蛋白 (CRP)、一氧化氮 (NO)、eNOS、p22-phox 和 SOD 基因表达水平以及内皮祖细胞 (EPC) 计数。我们证明了患有 GDM 的女性存在母体循环 EPC 计数减少、母体血液中可溶性粘附分子增加、母体和脐带血中 SOD 表达减少以及母体和脐带血中 eNOS 表达增加的情况。这些数据表明，GDM 女性及其胎儿氧化应激背后的分子机制似乎与非妊娠成人 2 型糖尿病 (DM) 的假设相似。
We tested the hypothesis that women with gestational diabetes mellitus (GDM) and their fetuses would demonstrate alterations in markers of endothelial nitric oxide synthase (eNOS) uncoupling, oxidative stress, and endothelial dysfunction and these changes would correlate with the levels of hyperglycemia through a pilot observational case-control study of women with GDM and their fetuses. Levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), C-reactive protein (CRP), nitric oxide (NO), eNOS, p22-phox, and SOD gene expression, and endothelial progenitor cells (EPC) counts in both maternal and cord blood were measured at the time of delivery in women with and without GDM. We demonstrated the presence of decreased maternal circulating EPC counts, increased soluble adhesion molecules in maternal blood, decreased SOD expression in both maternal and cord blood and increased eNOS expression in both maternal and cord blood in women with GDM. These data suggest that the molecular mechanisms behind oxidative stress in women with GDM and their fetuses appear similar to those hypothesized for non-pregnant adults with type 2 diabetes mellitus (DM).