Skeletal muscle ventricles: update after 18 months in circulation.
Skeletal muscle ventricles: update after 18 months in circulation.
复制标题
骨骼肌心室：循环 18 个月后更新。
DOI：
10.1111/j.1525-1594.1991.tb00740.x
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发表时间：
1991
影响因子：
2.4
通讯作者：
Stephenson,LW
中科院分区：
文献类型：
--
作者：
Ruggiero,R;Niinami,H;Pochettino,A;Hammond,RL;Hooper,TL;Lu,HP;Anderson,DR;Spanta,AD;Stephenson,LW
从犬背阔肌构建了骨骼肌心室（SMV），并将其连接到主动脉作为主动脉舒张反搏器。目前，一只狗仍然活着，SMV已经在循环中连续工作了18个月，没有血栓栓塞并发症的证据。在我们的实验室中使用模拟循环装置进行测试时，SMV能够执行心脏型工作，输出等于生理预负荷下左心室的输出。SMV已用于右侧心脏辅助。在急性实验中，这些心室有效地发挥作用，绕过心脏右侧长达8小时。最近，我们已经测试了SMV，长期使用它们在右侧循环中泵血，在撰写本文时，它们已被证明在这种配置中有效运行长达18天。SMV将来可能用作治疗左侧或右侧心力衰竭患者的方法。
Skeletal muscle ventricles (SMVs) have been constructed from canine latissimus dorsi muscle and connected to the aorta as aortic diastolic counterpulsators. Presently one dog remains alive and well with an SMV that has been functioning continuously in circulation for 18 months, without evidence of thromboembolic complications. SMVs are able to perform cardiac–type work with an output equal to that of the left ventricle at physiologic preloads, when tested with a mock circulation device in our laboratory. SMVs have been used for right sided cardiac assist. In acute experiments these ventricles have functioned effectively, bypassing the right side of the heart for up to 8 h. Most recently we have tested SMVs using them chronically to pump blood in the right–sided circulation, and at the time of writing they have been shown to function effectively in this configuration for up to 18 days. SMVs may be used in the future as a method of treating patients with left– or right–sided heart failure.