A community assessment of privacy preserving techniques for human genomes.
A community assessment of privacy preserving techniques for human genomes.
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DOI：
10.1186/1472-6947-14-s1-s1
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发表时间：
2014
影响因子：
3.5
通讯作者：
Tang H
中科院分区：
文献类型：
--
作者：
Jiang X;Zhao Y;Wang X;Malin B;Wang S;Ohno-Machado L;Tang H
为了回答严格保护生物医学数据的需要，我们组织了数据隐私和保护的关键评估倡议，作为一项社区努力来评估生物医学数据的隐私保护传播技术。我们关注的是如何在不破坏全基因组关联研究（GWAS）的效用或阻碍其传播的前提下，以保护数据供体隐私的方式共享汇总人类基因组数据（例如，等位基因频率）的挑战。具体来说，我们设计了两个问题来传播原始数据和分析结果，分别基于来自HapMap和个人基因组计划的公开数据。共有六支队伍参加了挑战。最终结果在iDASH（整合数据分析、“匿名化”和共享）国家生物医学计算中心的研讨会上发表。我们报告了挑战的结果和我们对当前基因组隐私保护技术的发现。
To answer the need for the rigorous protection of biomedical data, we organized the Critical Assessment of Data Privacy and Protection initiative as a community effort to evaluate privacy-preserving dissemination techniques for biomedical data. We focused on the challenge of sharing aggregate human genomic data (e.g., allele frequencies) in a way that preserves the privacy of the data donors, without undermining the utility of genome-wide association studies (GWAS) or impeding their dissemination. Specifically, we designed two problems for disseminating the raw data and the analysis outcome, respectively, based on publicly available data from HapMap and from the Personal Genome Project. A total of six teams participated in the challenges. The final results were presented at a workshop of the iDASH (integrating Data for Analysis, 'anonymization,' and SHaring) National Center for Biomedical Computing. We report the results of the challenge and our findings about the current genome privacy protection techniques.