BacFITBase: a database to assess the relevance of bacterial genes during host infection
BacFITBase: a database to assess the relevance of bacterial genes during host infection
复制标题
DOI：
10.1093/nar/gkz931
复制
发表时间：
2020-01-08
影响因子：
14.9
通讯作者：
Torrent Burgas, Marc
中科院分区：
文献类型：
--
作者：
Macho Rendon, Javier;Lang, Benjamin;Torrent Burgas, Marc
近年来，细菌感染在世界范围内呈上升趋势，在归因死亡和残疾调整生命年方面对人类福祉产生了相当大的影响。然而，细菌致病的许多机制仍然知之甚少。在这里，我们介绍了BacFITBase数据库，用于系统表征与宿主感染相关的细菌蛋白，旨在识别新的抗生素靶标。BacFITBase是人工管理的，包含超过90，000个条目，其中包含关于在一系列宿主物种体内感染条件下单个基因对细菌适应性的贡献的信息。这些数据收集自15项不同的研究，其中进行了转座子诱变，包括最优先的病原体，如鲍氏不动杆菌和空肠弯曲杆菌，据报道，这两种病原体的抗生素耐药性都在增加。总体而言，BacFITBase包括10种不同组织中15种病原菌和5种宿主脊椎动物的信息。
Bacterial infections have been on the rise worldwide in recent years and have a considerable impact on human well-being in terms of attributable deaths and disability-adjusted life years. Yet many mechanisms underlying bacterial pathogenesis are still poorly understood. Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets. BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host species. The data were collected from 15 different studies in which transposon mutagenesis was performed, including top-priority pathogens such as Acinetobacter baumannii and Campylobacter jejuni, for both of which increasing antibiotic resistance has been reported. Overall, BacFITBase includes information on 15 pathogenic bacteria and 5 host vertebrates across 10 different tissues.