Prevalence and treatment of psoriasis in the United Kingdom - A population-based study
Prevalence and treatment of psoriasis in the United Kingdom - A population-based study
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DOI：
10.1001/archderm.141.12.1537
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发表时间：
2005-12-01
影响因子：
--
通讯作者：
Margolis, D
中科院分区：
文献类型：
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作者：
Gelfand, JM;Weinstein, R;Margolis, D
目的：测量英国银屑病的患病率和治疗方法。设计：确定患病率的横断面研究和确定治疗模式的队列研究。设置：全科医生的门诊实践。患者：我们在分析中纳入了1987年至2002年在全科医生研究数据库中注册的所有患者。主要结果测量：银屑病的患病率和治疗。结果：我们确定了114521例银屑病患者的总人口为7533475例，产生的患病率为1.5%。与年轻男性患者相比，年轻女性患者的银屑病患病率增加更快，70岁及以上患者的患病率显著下降，无论性别如何。总体而言，91.8%诊断为银屑病的患者在全科医学研究数据库中首次诊断银屑病代码的日期或之后接受了银屑病治疗处方。大多数患者（55.2%）只收到1或2个处方银屑病后的第一年记录在全科医学研究database.Conclusions：银屑病的流行病学在全科医学研究数据库的人口是相似的其他流行病学研究银屑病在英国，美国和其他西方国家。由于其高患病率及其相关的处方治疗需求，牛皮癣带来了巨大的负担。另外的研究是必要的，以确定为什么银屑病的患病率在女性患者中增加得更快，并确定为什么患病率在70岁及以上的患者中下降。
Objective: To measure the prevalence and treatment of psoriasis in the United Kingdom.Design: Cross-sectional study to determine prevalence and cohort study to determine treatment patterns.Setting: Outpatient practices of general practitioners.Patients: We included in the analysis all patients who were registered with a general practitioner in the General Practice Research Database from 1987 to 2002.Main Outcome Measures: The prevalence and treatment of psoriasis.Results: We identified 114 521 patients with psoriasis of a total population of 7 533 475 patients, yielding a prevalence of 1.5%. The prevalence of psoriasis increases more rapidly in young female patients compared with young male patients and declines significantly in patients 70 years and older, regardless of sex. Overall, 91.8% of patients with a diagnosis of psoriasis received a prescription for psoriasis treatment on or after the date of their first diagnostic code of psoriasis in the General Practice Research Database. Most of the patients (55.2%) received only 1 or 2 prescriptions for psoriasis in the first year after psoriasis was documented in the General Practice Research Database.Conclusions: The epidemiology of psoriasis in the General Practice Research Database population is similar to that of other epidemiologic studies of psoriasis performed in the United Kingdom, the United States, and other Western countries. Psoriasis carries a substantial burden given its high prevalence and its associated need for prescription therapy. Additional studies are necessary to determine why the prevalence of psoriasis increases more rapidly in female patients and to determine why the prevalence decreases in patients 70 years and older.