Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive d
Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive d
复制标题
单侧慢性大脑大动脉狭窄闭塞症患者多体素质子磁共振波谱表观脑温度成像与正电子发射断层扫描脑血流和代谢成像对比
DOI：
10.1007/s00234-017-1890-3
复制
发表时间：
2017
期刊：
影响因子：
2.8
通讯作者：
Ogasawara K
中科院分区：
文献类型：
--
作者：
Nanba T;Nishimoto H;Yoshioka Y;Murakami T;Sasaki M;Uwano I;Fujiwara S;Terasaki K;Ogasawara K
本研究的目的是确定使用多体素质子磁共振（MR）波谱的表观脑温度成像与单侧慢性大脑主要动脉狭窄闭塞病患者深部白色物质的脑血流（CBF）和代谢成像是否相关。正电子发射断层扫描（PET）分别在35例患者。将一组5 × 5体素的感兴趣区域（ROI）放置在MR图像上，使每个边缘的体素行位于每个大脑半球半卵圆中心的深白色物质中。将PET图像与具有这些感兴趣区的MR图像进行配准，并使用图像分析软件自动重新切片。结果在位于深层白色的175个体素对中，大脑温度差（受累半球-对侧半球：ΔBT）与脑血容量（CBV）相关（r= 0.570）和氧摄取分数（OEF）比值（患侧半球/对侧半球）（r= 0.641）。我们排除了包含缺血性病变或脑脊液的体素，并计算了每位患者体素对的平均值。平均ΔBT与平均CBF（r=-0.376）、平均CBV（r= 0.702）和平均OEF比值（r= 0.774）相关。结论单侧大脑大动脉狭窄闭塞性疾病患者使用多体素质子磁共振波谱进行的表观脑温成像与深部白色物质的CBF和代谢成像相关。
PurposeThe purpose of the present study was to determine whether apparent brain temperature imaging using multi-voxel proton magnetic resonance (MR) spectroscopy correlates with cerebral blood flow (CBF) and metabolism imaging in the deep white matter of patients with unilateral chronic major cerebral artery steno-occlusive disease.MethodsApparent brain temperature and CBF and metabolism imaging were measured using proton MR spectroscopy and15O-positron emission tomography (PET), respectively, in 35 patients. A set of regions of interest (ROIs) of 5 × 5 voxels was placed on an MR image so that the voxel row at each edge was located in the deep white matter of the centrum semiovale in each cerebral hemisphere. PET images were co-registered with MR images with these ROIs and were re-sliced automatically using image analysis software.ResultsIn 175 voxel pairs located in the deep white matter, the brain temperature difference (affected hemisphere − contralateral hemisphere: ΔBT) was correlated with cerebral blood volume (CBV) (r= 0.570) and oxygen extraction fraction (OEF) ratios (affected hemisphere/contralateral hemisphere) (r= 0.641). We excluded voxels that contained ischemic lesions or cerebrospinal fluid and calculated the mean values of voxel pairs in each patient. The mean ΔBT was correlated with the mean CBF (r= − 0.376), mean CBV (r= 0.702), and mean OEF ratio (r= 0.774).ConclusionsApparent brain temperature imaging using multi-voxel proton MR spectroscopy was correlated with CBF and metabolism imaging in the deep white matter of patients with unilateral major cerebral artery steno-occlusive disease.