Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data.
Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data.
复制标题
DOI：
10.1371/journal.pone.0022097
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Jin L
中科院分区：
文献类型：
--
作者：
He Y;Li C;Amos CI;Xiong M;Ling H;Jin L
The genome-wide association study (GWAS) has become a routine approach for mapping disease risk loci with the advent of large-scale genotyping technologies. Multi-allelic haplotype markers can provide superior power compared with single-SNP markers in mapping disease loci. However, the application of haplotype-based analysis to GWAS is usually bottlenecked by prohibitive time cost for haplotype inference, also known as phasing. In this study, we developed an efficient approach to haplotype-based analysis in GWAS. By using a reference panel, our method accelerated the phasing process and reduced the potential bias generated by unrealistic assumptions in phasing process. The haplotype-based approach delivers great power and no type I error inflation for association studies. With only a medium-size reference panel, phasing error in our method is comparable to the genotyping error afforded by commercial genotyping solutions.
登录
查看更多内容
影响因子：
5.8
作者：
Brinza, D;Zelikovsky, A
通讯作者：
Zelikovsky, A
DOI：
10.1073/pnas.0501536102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Hageman, GS;Anderson, DH;Allikmets, R
通讯作者：
Allikmets, R
影响因子：
9.8
作者：
Minichiello, Mark J.;Durbin, Richard
通讯作者：
Durbin, Richard
影响因子：
5.8
作者：
Halperin, E;Eskin, E
通讯作者：
Eskin, E
影响因子：
7.6
作者：
Beuten, J;Payne, TJ;Li, MD
通讯作者：
Li, MD