Rapid establishment of aCOVID-19 convalescent plasma program in a regional health care delivery network
Rapid establishment of aCOVID-19 convalescent plasma program in a regional health care delivery network
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DOI：
10.1111/trf.16026
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发表时间：
2020-08-21
期刊：
影响因子：
2.9
通讯作者：
Katz, Louis
中科院分区：
文献类型：
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作者：
Blackall, Douglas;Wulff, Shephali;Katz, Louis
背景COVID-19恢复期血浆（CCP）是治疗SARS-CoV-2感染患者的一种有吸引力的方法。我们致力于为一个区域性的医疗保健机构网络迅速建立一个可持续的CCP输血计划。研究设计和方法启动了一个区域合作小组，以解决实施CCP输血计划所需的问题，并使该计划可持续发展。为了使该计划取得成功，需要广泛的医疗保健提供者，包括医生（重症监护、传染病、输血医学）、护士、药剂师、实验室工作人员和信息技术（IT）专家。结果CCP实施团队最初由4名成员组成，但根据与计划实施相关的不同问题，迅速发展到近20名参与者。总的来说，讨论了六个主要的实施“主题”：（a）各医院和主要研究者在国家新药研究方案中的注册;（B）与地区献血中心的合作;（c）有针对性地招募康复献血者;（d）与CCP订购、分配和输血的所有方面有关的信息技术问题;（e）优先考虑接受CCP的患者;和（f）CCP产品的评价，包括抗体特性和患者对治疗的反应。结论在开始的4周内，CCP在我们区域卫生保健提供系统的多家医院成功输血。建立了一个项目基础设施，使该项目在未来可持续发展。这种方法对于需要快速实施的多机构方案的成功具有更广泛的影响。
Background COVID-19 convalescent plasma (CCP) represents an appealing approach to the treatment of patients with infections due to SARS-CoV-2. We endeavored to quickly establish a sustainable CCP transfusion program for a regional network of health care facilities. Study design and methods A regional collaborative group was activated to address the issues necessary to implementing a CCP transfusion program and making the program sustainable. A wide range of health care providers including physicians (critical care, infectious disease, transfusion medicine), nurses, pharmacists, laboratorians, and information technology (IT) specialists were required to make the program a success. Results The CCP implementation team initially consisted of four members but quickly grew to a group of nearly 20 participants based on different issues related to program implementation. Overall, six major implementation "themes" were addressed: (a) registration of individual hospitals and principal investigators with a national investigational new drug research protocol; (b) collaboration with a regional blood donor center; (c) targeted recruitment of convalesced donors; (d) IT issues related to all aspects of CCP ordering, distribution, and transfusion; (e) prioritization of patients to receive CCP; and (f) evaluation of CCP products including antibody characteristics and patient response to therapy. Conclusion Within 4 weeks of initiation, CCP was successfully transfused at multiple hospitals in our regional health care delivery system. A program infrastructure was established that will make this program sustainable into the future. This approach has broader implications for the success of multi-institutional programs requiring rapid implementation.