Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery
Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery
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DOI：
10.1016/j.jconrel.2011.02.024
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发表时间：
2011-06-10
影响因子：
10.8
通讯作者：
De Smedt, Stefaan C.
中科院分区：
文献类型：
--
作者：
Geers, Bart;Lentacker, Ine;De Smedt, Stefaan C.
载脂质体微泡作为超声引导给药的一种很有前途的给药平台最近被引入。在本文中，我们设计脂质体负载（脂壳）微泡通过简单的自组装在所涉及的化合物在一个步骤的过程。我们彻底表征了微泡的脂质体负载，并使用阿霉素（DOX）作为模型药物评估了这种材料的细胞杀伤效率。重要的是，我们观察到负载DOX脂质体的微泡即使在非常低剂量的DOX下也能杀死黑色素瘤细胞。这些发现清楚地证明了载脂质体微泡用于超声靶向药物递送到癌症组织的潜力。(C) 2011 Elsevier B.V.版权所有
Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughly characterized the liposome-loading of the microbubbles and evaluated the cell killing efficiency of this material using doxorubicin (DOX) as a model drug. Importantly, we observed that the DOX liposome-loaded microbubbles allowed killing of melanoma cells even at very low doses of DOX. These findings clearly prove the potential of liposome-loaded microbubbles for ultrasound targeted drug delivery to cancer tissues. (C) 2011 Elsevier B.V. All rights reserved.