Dopamine receptor polymorphism modulates the relation between antenatal maternal anxiety and fetal movement.
Dopamine receptor polymorphism modulates the relation between antenatal maternal anxiety and fetal movement.
复制标题
多巴胺受体多态性调节产前母亲焦虑与胎儿运动之间的关系。
DOI：
10.1002/dev.21428
复制
发表时间：
2016
影响因子：
2.2
通讯作者：
Faraone,Stephen
中科院分区：
文献类型：
--
作者：
Kaitz,Marsha;Mankuta,David;Rokem,AnnMarie;Faraone,Stephen
我们确定胎儿基因型（多巴胺 D4 受体；DRD4）和母亲怀孕期间的焦虑的组合是否与胎儿行为相关。 206 名孕妇接受了超声波检查。胎儿运动测量（运动频率、总活动量、运动持续时间和最长安静时间）来自离线编码。发现了 DRD4-III 多态性的调节作用：结果表明，在携带 7R 等位基因的胎儿中，较高水平的产前母亲焦虑症状与更频繁的胎动有关，但在携带较短等位基因的胎儿中则不然。总活动并未显示出 DRD4 的完全调节作用，尽管该测量值与带有 7R 等位基因的焦虑组胎儿中母亲的焦虑相关。不存在于没有这两种因素的胎儿中。这些发现提供了 GXE 相互作用与胎儿行为相关的第一个证据。结果还表明，有些人天生比其他人更容易受到子宫环境的影响。
We determined whether the combination of fetal genotype (dopamine D4 receptor; DRD4) and mothers’ anxiety during pregnancy is associated with fetal behavior. Two hundred and six pregnant women underwent an ultrasound exam. Fetal movement measures (Movement Frequency, Total Activity, Movement Duration, and Longest Quiet Time) were derived from off‐line coding. A moderating role of the DRD4‐III polymorphism was found: Results indicate that higher levels of antenatal maternal anxiety symptoms were associated with more frequent fetal movements among fetuses carrying a 7R allele, but not among fetuses carrying shorter alleles. Total Activity did not show full moderation by DRD4, though the measure was correlated with maternal anxiety among fetuses in the Anxious Group with a 7R allele; not among fetuses without both factors. The findings provide the first evidence of a GXE interaction in association with fetal behavior. Results also demonstrate that some individuals are inherently more susceptible to uterine environmental influences than are others.