Incidence Rates of Clinically Significant Tinnitus: 10-Year Trend From a Cohort Study in England
Incidence Rates of Clinically Significant Tinnitus: 10-Year Trend From a Cohort Study in England
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DOI：
10.1097/aud.0000000000000121
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发表时间：
2015-05-01
期刊：
影响因子：
3.7
通讯作者：
Hall, Deborah A.
中科院分区：
文献类型：
--
作者：
Martinez, Carlos;Wallenhorst, Christopher;Hall, Deborah A.
目的：调查耳鸣的发病率，负担的卫生服务在England.Design：这是一个观察性研究的470万居民的英国85岁以下的人有风险发展临床显着耳鸣（sigT）。SigT的定义是出院时主要诊断为耳鸣，或耳鸣的初级护理记录，随后在28天内进行相关的医疗随访。使用的数据库是临床实践研究数据链，个体记录与医院事件统计的其他数据相关联。观察期为2002年1月1日至2011年12月31日。年龄，性别，和日历年特定的发病率和累积发病率的sigT估计和预测的sigT的新病例之间2012年和2021年performed.Results：有14,303例事件中确定sigT的2650万人年的观察。sigT的发病率为每10，000人年5.4例新发病例（95%置信区间：5.3至5.5）。发病率不取决于性别，但随着年龄的增长而增加，在60至69岁年龄组中达到峰值，每10 000人中有11.4人。sigT的年发病率从2002年的4.5/10，000人年增加到2011年的6.6/10，000人年。sigT的10年累积发病率为每10，000名居民58.4例（95%置信区间：57.4至59.4）。预计2012年至2021年期间，英国将发生近324，000例新的sigT病例。结论：近年来，耳鸣给医疗保健系统带来了负担。基于人群的研究提供了关键的基础证据;强调需要进一步研究，以解决这种异质性疾病的有效诊断和临床管理问题。
Objective: To investigate the incidence of tinnitus that burdens the health service in England.Design: This was an observational study of 4.7 million residents of England under 85 years of age who were at risk for developing clinically significant tinnitus (sigT). SigT was defined by a discharge from hospital with a primary diagnosis of tinnitus, or a primary care recording of tinnitus with subsequent related medical follow-up within 28 days. The database used was the Clinical Practice Research Datalink and individual records were linked to additional data from the Hospital Episode Statistics. The observational period was from January 1, 2002 to December 31, 2011. Age-, gender-, and calendar year-specific incidence rates for and cumulative incidences of sigT were estimated and a projection of new cases of sigT between 2012 and 2021 was performed.Results: There were 14,303 incident cases of sigT identified among 26.5 million person-years of observation. The incidence rate was 5.4 new cases of sigT per 10,000 person-years (95% confidence interval: 5.3 to 5.5). The incidence rate did not depend on gender but increased with age, peaking at 11.4 per 10,000 in the age group 60 to 69 years. The annual incidence rate of sigT increased from 4.5 per 10,000 person-years in 2002 to 6.6 per 10,000 person-years in 2011. The 10-year cumulative incidence of sigT was 58.4 cases (95% confidence interval: 57.4 to 59.4) per 10,000 residents. Nearly 324,000 new cases of sigT are expected to occur in England between 2012 and 2021.Conclusions: Tinnitus presents a burden to the health care system that has been rising in recent years. Population-based studies provide crucial underpinning evidence; highlighting the need for further research to address issues around effective diagnosis and clinical management of this heterogeneous condition.