PRIOR IMMUNITY-RELATED MEDICAL CONDITIONS AND PANCREATIC-CANCER RISK IN SHANGHAI
PRIOR IMMUNITY-RELATED MEDICAL CONDITIONS AND PANCREATIC-CANCER RISK IN SHANGHAI
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DOI：
10.1002/ijc.2910630305
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发表时间：
1995-11-03
影响因子：
6.4
通讯作者：
GAO, YT
中科院分区：
文献类型：
--
作者：
DAI, Q;ZHENG, W;GAO, YT
为探讨免疫相关疾病在胰腺癌病因中的作用，我们分析了1992年至1993年在上海进行的一项以人群为基础的胰腺癌病例对照研究的数据。选择自身免疫性疾病和过敏性疾病的既往史的信息，从108例胰腺癌事件和275年龄和性别频率匹配的控制，通过面对面的访谈，使用结构化问卷。既往自身免疫性疾病史与胰腺癌风险升高2倍相关（95% CI = 1.0-4.2），表明报告疾病数量存在剂量-反应关系。相反，既往过敏性疾病史与风险降低相关（OR = 0.6，95% CI = 0.4-1.1）。药物过敏可能是一个例外，几乎所有过敏性疾病都存在这种负相关，尽管没有一个OR具有统计学显著性。这项研究表明宿主免疫功能可能参与胰腺癌的病因。这些观察到的协会的机制进行进一步调查是必要的。(C)1995年Wiley-Liss，Inc.
To investigate the role of immunity-related medical conditions in the etiology of pancreatic cancer, we analyzed data from a population-based case-control study of pancreatic cancer conducted in Shanghai during 1992 and 1993. Information on prior histories of selected auto-immune diseases and allergic conditions was obtained from 108 incident pancreatic-cancer cases and 275 age- and gender-frequency matched controls by face-to-face interviews using a structured questionnaire. A prior history of auto-immune diseases was associated with a 2-fold elevated risk of pancreatic cancer (95% CI = 1.0-4.2), with an indication of a dose-response relation for the number of reported diseases. In contrast, a prior history of allergic condition was related to reduced risk (OR = 0.6, 95% CI = 0.4-1.1). With the possible exception of drug allergy, such an inverse association was seen for virtually all allergic conditions, although none of the OR was statistically significant. This study suggests that host immune function may be involved in the etiology of pancreatic cancer. Further investigations into the mechanism of these observed associations are warranted. (C) 1995 Wiley-Liss, Inc.