Not all the number of skeletal muscle fibers is determined prenatally.
Not all the number of skeletal muscle fibers is determined prenatally.
复制标题
并非所有骨骼肌纤维的数量都是在产前决定的
DOI：
10.1186/s12861-015-0091-8
复制
发表时间：
2015-11-11
影响因子：
--
通讯作者：
Mo D
中科院分区：
文献类型：
--
作者：
Li M;Zhou X;Chen Y;Nie Y;Huang H;Chen H;Mo D
BackgroundThe investigation of skeletal muscle development is of importance in stock farming and biomedicine. It is still ambiguous that whether animals are born with the full set of skeletal muscle fibers or if the number of myofibers continues to increase postnatally.ResultsHere, an inducible lineage-tracing system was employed to monitor the changes of myofiber number in various skeletal muscles during development. We confirm that the total myofiber number of longissimus dorsi, gastrocnemius and rectus femoris is determined prenatally. However, tibialis anterior and extensor digitorum longus have a different development pattern, and their myofiber number still increases in the first postnatal week and then remains stable afterwards.ConclusionsOur results highlight different development time frames of anatomically distinct skeletal muscles.
