ANTITUMOUR POLYSACCHARIDE DERIVED CHEMICALLY FROM NATURAL GLUCAN (PACHYMAN)

ANTITUMOUR POLYSACCHARIDE DERIVED CHEMICALLY FROM NATURAL GLUCAN (PACHYMAN)
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DOI：
10.1038/225943a0
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发表时间：
1970-01-01
期刊：
NATURE
影响因子：
64.8
通讯作者：
FUKUOKA, F
FUKUOKA, F
中科院分区：
综合性期刊1区
文献类型：
--
作者：
CHIHARA, G;HAMURO, J;FUKUOKA, F

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我们报道过1从香菇中提取的香菇多糖（Lentinus edodes（Berk.）唱歌（一种在日本很受欢迎的食用蘑菇）对小鼠皮下移植的肉瘤180具有很强的抗肿瘤活性，在10次1毫克/公斤剂量后，观察到肿瘤几乎完全消退。香菇多糖是一种β-（1→3）-连接的线性葡聚糖，根据光散射方法，其分子量为950，000 - 1，050，000。
WE have reported1that the polysaccharide lentinan obtained fromLentinus edodes(Berk.) Sing. (a popular edible mushroom in Japan) had a strong antitumour activity against sarcoma 180 implanted subcutaneously in mice, and that almost complete regression of the tumours had been observed after ten doses of 1 mg/kg. Lentinan is a β-(1→3)-linked linear glucan having a molecular weight of 950,000–1,050,000 according to light scattering methods.