CANCELLOUS BONE REMODELING IN TYPE-I (POSTMENOPAUSAL) OSTEOPOROSIS - QUANTITATIVE ASSESSMENT OF RATES OF FORMATION, RESORPTION, AND BONE LOSS AT TISSUE AND CELLULAR-LEVELS
CANCELLOUS BONE REMODELING IN TYPE-I (POSTMENOPAUSAL) OSTEOPOROSIS - QUANTITATIVE ASSESSMENT OF RATES OF FORMATION, RESORPTION, AND BONE LOSS AT TISSUE AND CELLULAR-LEVELS
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DOI：
10.1002/jbmr.5650050402
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发表时间：
1990-04-01
影响因子：
6.2
通讯作者：
RIGGS, BL
中科院分区：
文献类型：
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作者：
ERIKSEN, EF;HODGSON, SF;RIGGS, BL
I型（绝经后）骨质疏松症骨丢失的细胞机制是非常有争议的。我们试图通过一种新的组织形态计量学方法评估89名骨质疏松症妇女（平均年龄± 10岁）髂骨松质骨的形成和吸收率来解决这个问题。SD，66 . ±. 6岁）和32名仔细选择的正常绝经后妇女（64 . 6年）。在骨质疏松妇女中，骨吸收率在细胞水平上增加了39%（P < 0.05），在组织水平上增加了67%（P < 0.05），而骨形成在组织水平上没有变化，但在细胞（成骨细胞）水平上减少了14%（P < 0.01）。这种明显的重塑失衡（P < 0.001）可能因新重塑灶激活频率增加45%（P < 0.1）而加剧。这些异常与高松质骨丢失率相关（中位数为5.8%/年，对照组为0.1%/年）。因此，I型骨质疏松症中松质骨的加速损失是由于骨吸收增加和骨形成的充分补偿的组合。
The cellular mechanism for bone loss in type I (postmenopausal) osteoporosis are highly controversial. We attempted to resolve this by assessing rates of formation and resorption of iliac cancellous bone by a new histomorphometric method in 89 women with osteoporosis (mean age .+-. SD, 66 .+-. 6 years) and in 32 carefully selected normal postmenopausal women (64 .+-. 6 years). In the osteoporotic women, bone resorption rate was increased by 39% (P < 0.05) at the cellular level and by 67% (p < 0.05) at the tissue level, whereas bone formation was unchanged at the tissue level but decreased by 14% (P < 0.01) at the cellular (osteoblast) levels. This pronounced remodeling imbalance (P < 0.001) was probably exacerbated by a 45% increase (P < 0.1) in activation frequency of new remodeling foci. These abnormalities were associated with a high rate of cancellous bone loss (median, 5.8%/year versus 0.1% year in controls). Thus, accelerated loss of cancellous bone in type I osteoporosis results from the combination of increased bone resorption and in adequate compensation by bone formation.