The effect of metabolic inhibitors on retinal adhesion and subretinal fluid resorption.
The effect of metabolic inhibitors on retinal adhesion and subretinal fluid resorption.
复制标题
代谢抑制剂对视网膜粘附和视网膜下液体吸收的影响。
DOI：
--
复制
发表时间：
1980
影响因子：
4.4
通讯作者：
D. Cohen
中科院分区：
文献类型：
--
作者：
M. Marmor;A. S. Abdul;D. Cohen
用两种实验技术对荷兰兔视网膜粘连和视网膜下液的吸收进行了研究。首先，通过用微量移液管在视网膜下注射少量液体，在体内制备小的局部脱膜，并监测脱膜再吸收的时间。在第二种方法中，将眼杯条保持在生理浴介质中，并测量将视网膜从色素上皮剥离所需的力。使用这些技术，我们已经发现，这两种机制，以消除视网膜下液和维持视网膜粘连在体外被增强暴露于哇巴因，被抑制暴露于氰化物，并被抑制的生理介质与生理盐水的替代。这些数据表明，代谢系统可以同时水化和水化视网膜下腔，并且生理盐水中缺少一些对维持正常粘连很重要的因素。
Retinal adhesion and the resorption of subretinal fluid were studied in Dutch rabbits, with two experimental techniques. In the first, small local detachments were made in vivo by injecting a small amount of fluid under the retina with a micropipette, and the time for resorption of the detachment was monitored. In the second, strips of eyecup were maintained in a physiologic bathing medium, and the force required to peel retina from the pigment epithelium was measured. Using these techniques, we have found that both the mechanisms for removing subretinal fluid and for maintaining retinal adhesion in vitro are enhanced by exposure to ouabain, are inhibited by exposure to cyanide, and are inhibited by the replacement of the physiologic medium with normal saline. These data suggest that metabolic systems may simultaneously hydrate and dehydrate the subretinal space and that some factors which are important to the maintenance of normal adhesion are missing from normal saline.