Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women
Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women
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DOI：
10.1111/j.1460-9568.2006.05206.x
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发表时间：
2006-12-01
影响因子：
3.4
通讯作者：
Holstege, Gert
中科院分区：
文献类型：
--
作者：
Georgiadis, Janniko R.;Kortekaas, Rudie;Holstege, Gert
一般来说，关于大脑区域与人类性行为有关的知识严重缺乏，尤其是女性性高潮。我们使用[(15)O]-H(2)O正电子发射断层扫描测量了12名健康女性在非性休息状态、阴蒂诱导性高潮、性阴蒂刺激（性唤起控制）和模仿性高潮（运动输出控制）时的区域脑血流量（rCBF）。性表现和性高潮的脑外标记是直肠压变异性（RPstd）和性唤起感知水平（PSA）。阴蒂性刺激（与休息相比）显著增加了左侧第二和右侧背初级体感觉皮层的rCBF，提供了新皮层处理性阴蒂信息的第一个解释。相比之下，与对照组（阴蒂刺激和性高潮模仿）相比，高潮主要与新皮层rCBF的深度减少有关，特别是在左侧眶额皮质、颞下回和颞前极。左小脑深部核RPstd与rCBF、中脑腹侧和右侧尾状核PSA与rCBF呈显著正相关。我们认为，在女性性高潮期间，左侧眶额皮质的血流量减少表明行为抑制解除，而颞叶的失活与高性唤起直接相关。此外，小脑深部核可能参与性高潮特异性肌肉收缩，而腹侧中脑和右侧尾状核的参与表明多巴胺在女性性唤起和性高潮中的作用。
There is a severe lack of knowledge regarding the brain regions involved in human sexual performance in general, and female orgasm in particular. We used [(15)O]-H(2)O positron emission tomography to measure regional cerebral blood flow (rCBF) in 12 healthy women during a nonsexual resting state, clitorally induced orgasm, sexual clitoral stimulation (sexual arousal control) and imitation of orgasm (motor output control). Extracerebral markers of sexual performance and orgasm were rectal pressure variability (RPstd) and perceived level of sexual arousal (PSA). Sexual stimulation of the clitoris (compared to rest) significantly increased rCBF in the left secondary and right dorsal primary somatosensory cortex, providing the first account of neocortical processing of sexual clitoral information. In contrast, orgasm was mainly associated with profound rCBF decreases in the neocortex when compared with the control conditions (clitoral stimulation and imitation of orgasm), particularly in the left lateral orbitofrontal cortex, inferior temporal gyrus and anterior temporal pole. Significant positive correlations were found between RPstd and rCBF in the left deep cerebellar nuclei, and between PSA and rCBF in the ventral midbrain and right caudate nucleus. We propose that decreased blood flow in the left lateral orbitofrontal cortex signifies behavioural disinhibition during orgasm in women, and that deactivation of the temporal lobe is directly related to high sexual arousal. In addition, the deep cerebellar nuclei may be involved in orgasm-specific muscle contractions while the involvement of the ventral midbrain and right caudate nucleus suggests a role for dopamine in female sexual arousal and orgasm.