Minute dosages of ανβ3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits
Minute dosages of ανβ3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits
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DOI：
10.1096/fj.07-103929
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发表时间：
2008-08-01
期刊：
影响因子：
4.8
通讯作者：
Lanza, Gregory M.
中科院分区：
文献类型：
--
作者：
Winter, Patrick M.;Schmieder, Anne H.;Lanza, Gregory M.
福马西林在癌症模型和临床试验中抑制血管生成，但它与全身剂量的神经毒性有关。在这项研究中，以α(NU)β(3)为靶点的烟美西林纳米粒被用来抑制新生血管和抑制VX-2腺癌的发展，并使用微小的药物剂量。分别于移植后第6、9、12天给予α(Nu)β(3)靶向雾化青霉素纳米粒(30mU g/kg)、非靶向雾化青霉素纳米粒(30mU g/kg)或生理盐水。在第16天，以α(Nu)β(3)为靶向的顺磁性纳米颗粒进行磁共振成像，以量化肿瘤大小并评估新生血管。与三个对照组相比，接受α(Nu)β(3)靶向雾化青霉素纳米粒(470+/-120 mm(3))的兔肿瘤体积缩小：非靶向雾化青霉素纳米粒(1370+/-300mm3，P
Fumagillin suppresses angiogenesis in cancer models and clinical trials, but it is associated with neurotoxicity at systemic doses. In this study, alpha(nu)beta(3)-targeted fumagillin nanoparticles were used to suppress the neovasculature and inhibit Vx-2 adenocarcinoma development using minute drug doses. Tumorbearing rabbits were treated on days 6, 9, and 12 postimplantation with alpha(nu)beta(3)-targeted fumagillin nanoparticles (30 mu g/kg), alpha(nu)beta(3)-targeted nanoparticles without drug, nontargeted fumagillin nanoparticles (30 mu g/kg) or saline. On day 16, MRI was performed with alpha(nu)beta(3)-targeted paramagnetic nanoparticles to quantify tumor size and assess neovascularity. Tumor volume was reduced among rabbits receiving alpha(nu)beta(3)-targeted fumagillin nanoparticles (470 +/- 120 mm(3)) compared with the three control groups: nontargeted fumagillin nanoparticles (1370 +/- 300 mm3, P