Alteration of serum lipid profile and its prognostic value in head and neck squamous cell carcinoma
Alteration of serum lipid profile and its prognostic value in head and neck squamous cell carcinoma
复制标题
头颈鳞状细胞癌血清脂质谱的改变及其预后价值。
DOI：
10.1111/jop.12344
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发表时间：
2016-03-01
影响因子：
3.3
通讯作者：
Song, Xiaomeng
中科院分区：
文献类型：
--
作者：
Li, Gang;Da, Mingjie;Song, Xiaomeng
研究背景多种血清脂质成分与肿瘤的发生发展有关。然而，血脂成分在头颈部鳞状细胞癌中的预后意义尚不清楚。在这里，我们调查了血脂谱在诊断和总生存率的patients.MethodsThe研究人群的预测价值包括136例病理证实的头颈部鳞状细胞癌病例诊断之间的2009年和2014年在三级医疗中心。比较术前患者与年龄、性别相匹配的正常对照组血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A、载脂蛋白B、脂蛋白（a）水平。分析血脂谱及其与临床参数的相关性。结果口腔癌患者血清胆固醇、低密度脂蛋白、载脂蛋白A、载脂蛋白B水平明显低于对照组（P
BackgroundSeveral serum lipid components have been implicated in the development of cancer. However, the prognostic significance of serum lipid components in head and neck squamous cell carcinoma is unknown. Here, we investigated the predictive value of serum lipid profile at diagnosis and in the overall survival of the patients.MethodsThe study population consists of 136 pathologically confirmed head and neck squamous cell carcinoma cases diagnosed between years 2009 and 2014 at a tertiary medical center. Levels of preoperative serum lipid component's total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, apolipoprotein A, apolipoprotein B, and lipoprotein (a) were compared between patients and normal controls matched for age and gender. Serum lipid profiles and their association with clinical parameters were analyzed. The effects of the serum lipid components on survival were examined using the proportional hazards regression model to estimate hazard ratio.ResultsSignificant lower levels of cholesterol, low-density lipoprotein, apolipoprotein A, and apolipoprotein B were found in patients with oral cancer (P