PREVALENCE OF AMPLIFICATION OF THE ONCOGENES C-MYC, HER2 NEU, AND INT-2 IN 1000 HUMAN BREAST-TUMORS - CORRELATION WITH STEROID-RECEPTORS
PREVALENCE OF AMPLIFICATION OF THE ONCOGENES C-MYC, HER2 NEU, AND INT-2 IN 1000 HUMAN BREAST-TUMORS - CORRELATION WITH STEROID-RECEPTORS
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DOI：
10.1016/s0959-8049(05)80129-7
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发表时间：
1992-02-01
影响因子：
8.4
通讯作者：
FOEKENS, JA
中科院分区：
文献类型：
--
作者：
BERNS, EMJJ;KLIJN, JGM;FOEKENS, JA
文献中描述的癌基因扩增的频率显示出很大的波动，这可能归因于对相对较小系列肿瘤的研究，患者亚组的选择，或者，特别是在回顾性研究中，从肿瘤库中选择肿瘤材料。 为了解决这个问题，我们已经研究了c-myc，HER 2/neu和int-2/bcl-1基因的扩增在一系列的1052收集人类乳腺肿瘤。 在这一系列收集的肿瘤中，回顾性和前瞻性亚组的大小相等。在所有研究的乳腺癌标本中，c-myc扩增率为17.1%，HER 2/neu扩增率为18.7%，int-2/bcl-1扩增率为14.1%。 在回顾性亚组中，c-myc、HER 2/neu和int-2/bcl-1的扩增发生率分别为18.1%、22.6%和11.6%，而在前瞻性亚组中，c-myc、HER 2/neu和int-2/bcl-1的扩增发生率分别为16.1%、15.1%和16.3%。 HER 2/neu扩增与雌激素受体（ER）和孕激素受体（PR）状态呈负相关（P < 0.0001;两者均如此），c-myc扩增在PR阴性亚群中更为普遍（P < 0.05），int-2/bcl-1扩增与ER状态呈正相关（P < 0.001）。
The frequency of oncogene amplification described in the literature shows a large fluctuation, which could be attributed to the study of relatively small series of tumours, to selection of subgroups of patients, or, especially in retrospective studies, to selection of tumour material from the tumour-bank. To address this question, we have studied amplification of c-myc, HER2/neu and int-2/bcl-1 genes in a series of 1052 collected human breast tumours. The retrospective and prospective subgroups in this collected series of tumours were of equal size. c-myc was amplified in 17.1%, HER2/neu in 18.7% and int-2/bcl-1 in 14.1%, of all breast cancer specimens studied. In the retrospective subgroup the prevalence of amplification was 18.1% for c-myc; 22.6% for HER2/neu and 11.6% for int-2/bcl-1, whereas in the prospective subgroup an incidence of amplification of 16.1%, 15.1% and 16.3% for c-myc, HER2/neu and int-2/bcl-1, respectively was observed. HER2/neu amplification was negatively correlated with oestrogen receptor (ER) and progesterone receptor (PR) status (P < 0.0001; for both), c-myc amplification was more prevalent in the PR-negative subpopulation (P < 0.05) and int-2/bcl-1 amplification was positively correlated with ER status (P < 0.001).