ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)
ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)
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DOI：
10.1111/j.1538-7836.2007.02579.x
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发表时间：
2007-07-01
影响因子：
10.4
通讯作者：
Folsom, A. R.
中科院分区：
文献类型：
--
作者：
Ohira, T.;Cushman, M.;Folsom, A. R.
背景资料：许多病例对照研究报道，静脉血栓栓塞症（VTE）患者中非O型血的患病率高于对照组，但这种关联的潜在机制或效应修饰因子尚未完全确定。患者/方法：采用巢式病例对照设计，结合社区动脉粥样硬化风险和心血管健康研究队列，对492名随后发生VTE的参与者和1008名未发生VTE的参与者的事件前血液样本进行ABO血型和其他VTE风险因素测量。结果：64.4%的病例组和52.5%的对照组为非O型血。在对照组中，非O型血组的凝血因子VIII c（FVIIIc）和血管性血友病因子的平均值高于O型血组。与O型血相比，非O型血VTE的年龄校正比值比（OR）为1.64（95%CI，1.32-2.05），两项母研究和种族组相似。进一步调整性别、种族、体重指数、糖尿病和FVIIIc使OR降低：1.31（95% CI，1.02-1.68）。莱顿因子V（FV Leiden）似乎以超累加方式改变了非O型血型与VTE的相关性，具有两种风险因素的年龄、性别和种族调整OR为6.77（95%CI，3.65-12.6）。结论：非O型血与静脉血栓栓塞的风险独立相关，并增加了与FV莱顿相关的风险。
Background: Numerous case-control studies have reported higher prevalence of non-O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect modifiers for the association are not fully established. Patients/methods: Using a nested case-control design combining the Atherosclerosis Risk in Communities and the Cardiovascular Health Study cohort, ABO blood type and other VTE risk factors were measured on pre-event blood samples of 492 participants who subsequently developed VTE and 1008 participants who remained free of VTE. Results: A total of 64.4% of cases and 52.5% of controls had non-O blood type. Among controls, mean values of factor VIIIc (FVIIIc) and von Willebrand factor among the non-O blood type group were higher than among the O group. Compared with O blood type, the age-adjusted odds ratio (OR) of VTE for non-O blood type was 1.64 (95% CI, 1.32-2.05) and was similar for the two parent studies and race groups. Further adjustment for sex, race, body mass index, diabetes mellitus and FVIIIc reduced the OR: 1.31 (95% CI, 1.02-1.68). Factor V Leiden (FV Leiden) appeared to modify the non-O blood type association with VTE in a supra-additive fashion, with an age-, sex- and race-adjusted OR of 6.77 (95% CI, 3.65-12.6) for having both risk factors. Conclusions: Non-O blood type was independently associated with risk of VTE, and added to the risk associated with FV Leiden.