Bio-based nitriles from the heterogeneously catalyzed oxidative decarboxylation of amino acids.
Bio-based nitriles from the heterogeneously catalyzed oxidative decarboxylation of amino acids.
复制标题
来自氨基酸非均相催化氧化脱羧的生物基腈。
作者：
Laurens Claes;Roman Matthessen;I. Rombouts;I. Stassen;Trees De Baerdemaeker;D. Depla;J. Delcour;B. Lagrain;D. D. De Vos
在[Ni，Al]层状双氢氧化物（LDH）、NH4 Br和H2 O2作为末端氧化剂上交换催化量的钨酸盐，通过原位卤化物氧化，在水溶液中实现了氨基酸氧化脱羧成腈。反应物与LDH催化剂之间的接近效应促进了卤化物氧化和氧化脱羧。多种氨基酸的转化率很高，通常达到90%以上。该体系对酰胺、醇，特别是羧酸、胺、胍等官能团经过适当中和后，具有良好的相容性。该多相催化体系成功地将淀粉工业中富含蛋白质的副产品转化为有用的生物基含氮化学品。
The oxidative decarboxylation of amino acids to nitriles was achieved in aqueous solution by in situ halide oxidation using catalytic amounts of tungstate exchanged on a [Ni,Al] layered double hydroxide (LDH), NH4 Br, and H2 O2 as the terminal oxidant. Both halide oxidation and oxidative decarboxylation were facilitated by proximity effects between the reactants and the LDH catalyst. A wide range of amino acids was converted with high yields, often >90 %. The nitrile selectivity was excellent, and the system is compatible with amide, alcohol, and in particular carboxylic acid, amine, and guanidine functional groups after appropriate neutralization. This heterogeneous catalytic system was applied successfully to convert a protein-rich byproduct from the starch industry into useful bio-based N-containing chemicals.