Mitochondrial fission, fusion, and stress.
Mitochondrial fission, fusion, and stress.
复制标题
DOI：
10.1126/science.1219855
复制
发表时间：
2012-08-31
期刊：
影响因子：
--
通讯作者：
van der Bliek AM
中科院分区：
文献类型：
--
作者：
Youle RJ;van der Bliek AM
当细胞经历代谢或环境应激时，线粒体分裂和融合在维持功能线粒体中起关键作用。融合通过混合部分受损线粒体的内容物作为互补的形式来帮助减轻压力。裂变是创造新的线粒体所必需的，但它也有助于通过去除受损的线粒体来进行质量控制，并且可以在高水平的细胞应激期间促进细胞凋亡。这些过程的中断会影响正常发育，并且它们与神经退行性疾病（如帕金森氏症）有关。
Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by mixing the contents of partially damaged mitochondria as a form of complementation. Fission is needed to create new mitochondria, but it also contributes to quality control by enabling the removal of damaged mitochondria and can facilitate apoptosis during high levels of cellular stress. Disruptions in these processes affect normal development, and they have been implicated in neurodegenerative diseases, such as Parkinson’s.