The Association of Telomere Length With Family Violence and Disruption
The Association of Telomere Length With Family Violence and Disruption
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DOI：
10.1542/peds.2013-3415
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发表时间：
2014-07-01
期刊：
影响因子：
8
通讯作者：
Theall, Katherine P.
中科院分区：
文献类型：
--
作者：
Drury, Stacy S.;Mabile, Emily;Theall, Katherine P.
背景：为了加强对早期逆境与负面健康之间的生物学机制的理解，我们研究了青少年家庭人际暴力与破坏和端粒长度之间的关系。选择这些特定的接触是因为它们在整个生命过程中与负面健康后果有确定的联系。方法：从大新奥尔良地区招募5至15岁的儿童，通过看护人报告评估家庭破裂和暴力的暴露程度。端粒长度，来自颊细胞DNA（颊端粒长度[bTL]），测定采用单色多重定量实时聚合酶链反应。测试了bTL与逆境暴露之间的关系（n = 80）。结果：人际暴力和家庭破裂的累积暴露与bTL相关。在控制其他社会人口因素后，暴露于家庭暴力和家庭破裂的儿童的bTL明显较短。目睹家庭暴力产生了特别强烈的影响。发现显著的性别交互作用（beta = -0.0086, SE = 0.0031， z检验= 22.79,P = 0.0053），分析显示仅在女孩中有影响。结论：bTL是儿童时期可检测到的逆境和适应负荷的分子生物标志物。目前的结果通过证明端粒对总体家庭领域内的逆境敏感，扩展了以前的研究。这些发现表明，家庭生态可能是一个重要的干预目标，以减少逆境对儿童生活的生物学影响。
BACKGROUND: To enhance the understanding of biological mechanisms connecting early adversity and negative health, we examine the association between family interpersonal violence and disruption and telomere length in youth. These specific exposures were selected because of their established links with negative health consequences across the life-course.METHODS: Children, age 5 to 15, were recruited from the greater New Orleans area, and exposure to family disruption and violence was assessed through caregiver report. Telomere length, from buccal cell DNA (buccal telomere length [bTL]), was determined by using monochrome multiplex quantitative real-time polymerase chain reaction. The association between bTL and adversity exposure was tested (n = 80).RESULTS: Cumulative exposure to interpersonal violence and family disruption was correlated with bTL. Controlling for other sociodemographic factors, bTL was significantly shorter in children with higher exposure to family violence and disruption. Witnessing family violence exerted a particularly potent impact. A significant gender interaction was found (beta = -0.0086, SE = 0.0031, z test = 22.79, P = .0053) and analysis revealed the effect only in girls.CONCLUSIONS: bTL is a molecular biomarker of adversity and allostatic load that is detectable in childhood. The present results extend previous studies by demonstrating that telomeres are sensitive to adversity within the overarching family domain. These findings suggest that the family ecology may be an important target for interventions to reduce the biological impact of adversity in the lives of children.